A Study to Investigate the Efficacy and Safety of an Anti-Interleukin-18 Monoclonal Antibody in the Treatment of Type 2 Diabetes Mellitus (Q35941368)

11 August 2017

A Study to Investigate the Efficacy and Safety of an Anti-Interleukin-18 Monoclonal Antibody in the Treatment of Type 2 Diabetes Mellitus (English)

1 reference

11 August 2017

1 reference

1 reference

Elizabeth A McKie

1

1 reference

11 August 2017

Juliet L Reid

2

1 reference

11 August 2017

Prafull C Mistry

3

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11 August 2017

Stephen L DeWall

4

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11 August 2017

Lee Abberley

5

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11 August 2017

Philip D Ambery

6

1 reference

11 August 2017

Blas Gil-Extremera

7

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11 August 2017

language of work or name

English

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publication date

1 March 2016

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11 August 2017

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11 August 2017

11

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11 August 2017

3

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11 August 2017

e0150018

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Creative Commons Attribution 4.0 International

11 August 2017

start time

1 March 2016

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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2 October 2017

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JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

2 October 2017

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Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study

2 October 2017

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Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans

2 October 2017

1 reference

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Associations of serum IL-18 levels with carotid intima-media thickness

2 October 2017

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Use and abuse of HOMA modeling

2 October 2017

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Inflammatory status and insulin resistance

2 October 2017

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The rising global burden of diabetes and its complications: estimates and projections to the year 2010

2 October 2017

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NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

2 October 2017

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Circulating inflammatory markers and the risk of vascular complications and mortality in people with type 2 diabetes and cardiovascular disease or risk factors: the ADVANCE study

11 July 2018

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Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-beta1 enhanced IL-18 expression in human renal proximal tubular epithelial cells.

24 September 2018

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Clinical significance of BRAF (V600E) mutation and Ki-67 labeling index in papillary thyroid carcinomas

24 September 2018

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Level and value of interleukin-18 after acute ischemic stroke

24 September 2018

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Plasma interleukin (IL)-18 concentrations is elevated in patients with previous myocardial infarction and related to severity of coronary atherosclerosis independently of C-reactive protein and IL-6.

24 September 2018

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Potential role of interleukin-18 in liver disease associated with insulin resistance

24 September 2018

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Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002.

24 September 2018

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Circulating IL-18 concentration is associated with insulin sensitivity and glucose tolerance through increased fat-free mass.

24 September 2018

1 reference

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Elevated interleukin-18 levels are associated with the metabolic syndrome independent of obesity and insulin resistance.

24 September 2018

1 reference

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Increased serum soluble tumor necrosis factor receptor levels are associated with insulin resistance in liver cirrhosis

24 September 2018

1 reference

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Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity.

24 September 2018

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Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis

24 September 2018

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Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus

24 September 2018

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Interleukin-6 gene polymorphism and insulin sensitivity

24 September 2018

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Is type II diabetes mellitus a disease of the innate immune system?

24 September 2018

1 reference

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Does interleukin-18 or tumour necrosis factor-α have an independent association with the risk of coronary heart disease? Results from a prospective study in New Zealand

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150018

Expression of Interleukin-18 in Human Atherosclerotic Plaques and Relation to Plaque Instability

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0150018

Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy

21 January 2018

1 reference

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Interleukin-18 contributes more closely to the progression of diabetic nephropathy than other diabetic complications

14 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26930607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Safety, tolerability, pharmacokinetics, and pharmacodynamics of single-dose antiinterleukin- 18 mAb GSK1070806 in healthy and obese subjects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26930607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26930607

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0150018

1 reference

11 August 2017

0 references

1 reference

11 August 2017

PubMed publication ID

26930607

1 reference