Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination (Q35815842)

10 August 2017

Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination (English)

1 reference

10 August 2017

1

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13 June 2020

Sandra J. Hewett

10

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13 June 2020

Casey T. Weaver

11

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13 June 2020

author name string

Brandi J Baker

2

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13 June 2020

Ryan E Doyle

3

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13 June 2020

Carson E Moseley

4

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13 June 2020

Christine M Sestero

5

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13 June 2020

Bryce P Johnston

6

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13 June 2020

Patrizia De Sarno

7

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13 June 2020

Andrew Tang

8

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13 June 2020

Igor Gembitsky

9

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13 June 2020

Chander Raman

12

1 reference

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13 June 2020

Tara M DeSilva

13

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13 June 2020

language of work or name

English

0 references

publication date

12 June 2015

1 reference

10 August 2017

Journal of Immunology

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13 June 2020

volume

195

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13 June 2020

issue

2

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13 June 2020

page(s)

450-463

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describes a project that uses

13 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4490999/fullTextXML

inferred from PubMed Central ID database lookup

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27 July 2018

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27 July 2018

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Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1β: implications for hypoxic neuronal injury

27 July 2018

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Nitric oxide and neuronal death

27 July 2018

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T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis

27 July 2018

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xCT deficiency accelerates chemically induced tumorigenesis

27 July 2018

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Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes

27 July 2018

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Extracellular redox modulation by regulatory T cells

27 July 2018

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Regulation of glutamate transport in developing rat oligodendrocytes.

27 July 2018

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Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB.

27 July 2018

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NMDA receptor blockade with memantine attenuates white matter injury in a rat model of periventricular leukomalacia

27 July 2018

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Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

27 July 2018

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Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.

27 July 2018

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Glutamate transporters: confining runaway excitation by shaping synaptic transmission

27 July 2018

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27 July 2018

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Inhibition of cystine uptake disrupts the growth of primary brain tumors

27 July 2018

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Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

27 July 2018

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Cytokine-induced cell death in human oligodendroglial cell lines. II: Alterations in gene expression induced by interferon-gamma and tumor necrosis factor-alpha

27 July 2018

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27 July 2018

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Glial glutamate transport as target for nitric oxide: consequences for neurotoxicity

27 July 2018

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27 July 2018

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27 July 2018

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Modulation of glutamate release from rat hippocampal synaptosomes by nitric oxide.

27 July 2018

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Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes.

27 July 2018

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Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

27 July 2018

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Inhibition of nitric oxide synthase for treatment of experimental autoimmune encephalomyelitis

27 July 2018

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Cytokine modulation of glial glutamate uptake: a possible involvement of nitric oxide

27 July 2018

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Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.

27 July 2018

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Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine

27 July 2018

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Suppression of experimental autoimmune encephalomyelitis by sulfasalazine.

27 July 2018

1 reference

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In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis

27 July 2018

1 reference

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Dysmyelinated axons in shiverer mice are highly vulnerable to alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor-mediated toxicity

24 September 2018

1 reference

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Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury

24 September 2018

1 reference

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System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes.

24 September 2018

1 reference

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GluR2-free alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors intensify demyelination in experimental autoimmune encephalomyelitis

24 September 2018

1 reference

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Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4490999

Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T.

24 September 2018

1 reference

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Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4490999

Cutting edge: critical role for CD5 in experimental autoimmune encephalomyelitis: inhibition of engagement reverses disease in mice.

24 September 2018

1 reference

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Cytokine-induced cell death in human oligodendroglial cell lines: I. Synergistic effects of IFN-gamma and TNF-alpha on apoptosis

24 September 2018

1 reference

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Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria

24 September 2018

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Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity.

24 September 2018

1 reference

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Ampa/kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter.

24 September 2018

1 reference

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Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4490999

Glioma cells release excitotoxic concentrations of glutamate.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4490999

The Mayo Clinic-Canadian Cooperative trial of sulfasalazine in active multiple sclerosis

24 September 2018

1 reference

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Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4490999

Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4490999

System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury

24 September 2018

1 reference

12 December 2020

Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing--remitting experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture

1 reference

12 December 2020

Suppression of experimental autoimmune encephalomyelitis by sulfasalazine

1 reference

12 December 2020

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide

1 reference

12 December 2020

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma

1 reference

12 December 2020

Interferon-gamma and interleukin-1 beta induce nitric oxide formation from primary mouse astrocytes

1 reference

12 December 2020

Expression of interferon-gamma receptors on murine oligodendrocytes and its regulation by cytokines and mitogens

1 reference

12 December 2020

Active immunization with proteolipid protein (190-209) induces ascending paralysing experimental autoimmune encephalomyelitis in C3H/HeJ mice

1 reference

12 December 2020

Autoimmune encephalomyelitis ameliorated by AMPA antagonists

1 reference

12 December 2020

Glutamate excitotoxicity in a model of multiple sclerosis

1 reference

12 December 2020

A neuropathological analysis of experimental autoimmune encephalomyelitis with predominant brain stem and cerebellar involvement and differences between active and passive induction

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12 December 2020

NBQX attenuates excitotoxic injury in developing white matter

1 reference

12 December 2020

Delayed Antagonism of AMPA/Kainate Receptors Reduces Long-Term Functional Deficits Resulting from Spinal Cord Trauma

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1401108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071560%20AND%20SRC:MED&resulttype=core&format=json

release_4honof2iizhtxm5gme563qx5ve

13 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4honof2iizhtxm5gme563qx5ve

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26071560%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

PubMed publication ID

26071560

1 reference