Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression. (Q35725108)

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28 December 2019

title

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression (English)

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28 December 2019

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1

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28 December 2019

Joachim Berger

4

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28 December 2019

Pedro Luis Herrera

6

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28 December 2019

Palle Serup

7

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28 December 2019

author name string

Jacob Hecksher-Sørensen

2

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28 December 2019

Jens Krull

3

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28 December 2019

Dietmar Riedel

5

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28 December 2019

Ahmed Mansouri

8

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28 December 2019

language of work or name

English

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publication date

1 April 2007

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Journal of Clinical Investigation

28 December 2019

published in

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28 December 2019

volume

117

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28 December 2019

issue

4

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28 December 2019

page(s)

961-970

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The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

28 December 2019

cites work

1 reference

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The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

12 July 2018

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Opposing actions of Arx and Pax4 in endocrine pancreas development

12 July 2018

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The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas.

12 July 2018

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12 July 2018

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Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors

12 July 2018

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Cellular biology of somatostatin receptors

12 July 2018

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Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

12 July 2018

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Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes

12 July 2018

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Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

12 July 2018

1 reference

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Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

12 July 2018

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neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas

12 July 2018

1 reference

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Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development

12 July 2018

1 reference

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Notch signalling controls pancreatic cell differentiation

12 July 2018

1 reference

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The hypothalamic satiety peptide CART is expressed in anorectic and non-anorectic pancreatic islet tumors and in the normal islet of Langerhans.

12 July 2018

1 reference

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

12 July 2018

1 reference

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Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells

12 July 2018

1 reference

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Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development

12 July 2018

1 reference

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neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS

12 July 2018

1 reference

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Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

12 July 2018

1 reference

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PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

12 July 2018

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The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

12 July 2018

1 reference

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Insulin-promoter-factor 1 is required for pancreas development in mice

12 July 2018

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Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes

12 July 2018

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MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.

12 July 2018

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Genetic determinants of pancreatic epsilon-cell development

25 September 2018

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Efficient recombination in pancreatic islets by a tamoxifen-inducible Cre-recombinase

25 September 2018

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Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes

25 September 2018

1 reference

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Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.

25 September 2018

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Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

25 September 2018

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An ultrastructural analysis of the developing embryonic pancreas

25 September 2018

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12 December 2020

Pancreatic polypeptide, glucagon and insulin secretion from the isolated perfused canine pancreas

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12 December 2020

Effect of somatostatin on exocrine pancreas evaluated on a total external pancreatic fistula of neoplastic origin

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12 December 2020

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

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12 December 2020

Precursor cells of mouse endocrine pancreas coexpress insulin, glucagon and the neuronal proteins tyrosine hydroxylase and neuropeptide Y, but not pancreatic polypeptide

1 reference

12 December 2020

Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor

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12 December 2020

The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas

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12 December 2020

Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas

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12 December 2020

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

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12 December 2020

Identifiers

DOI

10.1172/JCI29115

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17404619%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

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28 December 2019

PubMed publication ID

17404619

1 reference