Integrin signaling and mammary cell function (Q35676234)

9 August 2017

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title

Integrin signaling and mammary cell function (English)

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9 August 2017

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3

Charles H Streuli

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9 August 2017

Franziska Schatzmann

1

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9 August 2017

Rebecca Marlow

series ordinal

2

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9 August 2017

publication date

1 October 2003

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Journal of Mammary Gland Biology and Neoplasia

9 August 2017

published in

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9 August 2017

volume

8

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9 August 2017

issue

4

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9 August 2017

page(s)

395-408

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Signaling through focal adhesion kinase

9 August 2017

cites work

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12 December 2020

Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase

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12 December 2020

Expression of focal adhesion kinase gene and invasive cancer

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12 December 2020

A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading

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12 December 2020

Perturbation of beta1-integrin function in involuting mammary gland results in premature dedifferentiation of secretory epithelial cells

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12 December 2020

Focal adhesion kinase expression in oral cancers

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12 December 2020

Modulation of secreted proteins of mouse mammary epithelial cells by the collagenous substrata

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12 December 2020

Integrin control of cell cycle: a new role for ubiquitin ligase

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12 December 2020

Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane.

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12 December 2020

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

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12 December 2020

Cell-substrate interactions and signaling through ILK

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12 December 2020

Elevated focal adhesion kinase expression facilitates oral tumor cell invasion

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12 December 2020

Expression of extracellular matrix components is regulated by substratum

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12 December 2020

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

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12 December 2020

Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain

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12 December 2020

Integrins in development: moving on, responding to, and sticking to the extracellular matrix

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12 December 2020

Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1.

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12 December 2020

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

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12 December 2020

The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells

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12 December 2020

Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix.

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12 December 2020

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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12 December 2020

Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

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12 December 2020

Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization

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12 December 2020

The integrin-linked kinase (ILK) suppresses anoikis

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12 December 2020

Overexpression of the integrin-linked kinase mesenchymally transforms mammary epithelial cells

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12 December 2020

Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium

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12 December 2020

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

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12 December 2020

Developmental regulation of Bcl-2 family protein expression in the involuting mammary gland

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12 December 2020

Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling

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12 December 2020

Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis

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12 December 2020

Analysis of PINCH function inDrosophilademonstrates its requirement in integrin-dependent cellular processes

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12 December 2020

Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo

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12 December 2020

p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo.

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12 December 2020

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src

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12 December 2020

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

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12 December 2020

Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.

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12 December 2020

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions

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12 December 2020

Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways

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12 December 2020

Cell-matrix interactions during development and apoptosis of the mouse mammary gland in vivo.

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12 December 2020

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

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12 December 2020

The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

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12 December 2020

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

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12 December 2020

Ca2+-dependent localization of integrin-linked kinase to cell junctions in differentiating keratinocytes

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12 December 2020

Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors

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12 December 2020

Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes

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12 December 2020

Focal adhesions - the cytoskeletal connection

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12 December 2020

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

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12 December 2020

The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity

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12 December 2020

The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanoma

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12 December 2020

Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions

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12 December 2020

Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling

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12 December 2020

Apoptosis regulation in the mammary gland

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12 December 2020

Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

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12 December 2020

CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt

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12 December 2020

Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase

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12 December 2020

Laminin mediates tissue-specific gene expression in mammary epithelia

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12 December 2020

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

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12 December 2020

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

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12 December 2020

Early events in the anoikis program occur in the absence of caspase activation

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12 December 2020

Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase

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12 December 2020

Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells

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12 December 2020

Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation

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12 December 2020

Characterisation of integrin-linked kinase signalling in sporadic human colon cancer

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12 December 2020

Perturbation of beta1-integrin function alters the development of murine mammary gland

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12 December 2020

Integrins: bidirectional, allosteric signaling machines

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12 December 2020

Stimulation of phosphatidylinositol 3'-kinase association with foca adhesion kinase by platelet-derived growth factor.

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12 December 2020

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

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12 December 2020

The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).

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12 December 2020

Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice.

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12 December 2020

Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells

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12 December 2020

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.

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12 December 2020

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

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12 December 2020

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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12 December 2020

Growth defects induced by perturbation of beta1-integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways

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12 December 2020

C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes

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12 December 2020

Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity

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12 December 2020

Spatial and temporal changes in Bax subcellular localization during anoikis

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12 December 2020

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and β-catenin signaling pathways

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12 December 2020

Integrin signaling and cell growth control

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12 December 2020

Cell interactions with three-dimensional matrices

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12 December 2020

Focal adhesion kinase (p125FAK) expression correlates with motility of human melanoma cell lines

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12 December 2020

Disruption of epithelial cell-matrix interactions induces apoptosis

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12 December 2020

Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation

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12 December 2020

Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes

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12 December 2020

Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis

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12 December 2020

The N-termini of FAK and JAKs contain divergent band 4.1 domains

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12 December 2020

Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

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12 December 2020

The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondria

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12 December 2020

Influence of a reconstituted basement membrane and its components on casein gene expression and secretion in mouse mammary epithelial cells

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12 December 2020

Control of adhesion-dependent cell survival by focal adhesion kinase

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12 December 2020

Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

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12 December 2020

Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes

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12 December 2020

The extracellular matrix as a cell survival factor

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12 December 2020

Integrin signaling: it's where the action is.

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12 December 2020

The mammary gland: a unique organ for the study of development and tumorigenesis

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12 December 2020

The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.

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12 December 2020

Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells

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12 December 2020

Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

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12 December 2020

Signaling through focal adhesion kinase

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12 December 2020

Integrin-linked kinase is localized to cell-matrix focal adhesions but not cell-cell adhesion sites and the focal adhesion localization of integrin-linked kinase is regulated by the PINCH-binding ANK repeats

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12 December 2020

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

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12 December 2020

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

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12 December 2020

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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12 December 2020

pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk

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12 December 2020

The adaptor protein Shc couples a class of integrins to the control of cell cycle progression

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12 December 2020

Adhesion systems in normal breast and in invasive breast carcinoma

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12 December 2020

The protein kinase PKB/Akt regulates cell survival and apoptosis by inhibiting Bax conformational change

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12 December 2020

The integrin-actin connection, an eternal love affair

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12 December 2020

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase

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12 December 2020

A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction

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12 December 2020

Exploring the neighborhood: adhesion-coupled cell mechanosensors.

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12 December 2020

Laminin and beta1 integrins are crucial for normal mammary gland development in the mouse

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12 December 2020

Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinoma

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12 December 2020

C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo

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12 December 2020

Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation

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12 December 2020

Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis

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12 December 2020

The focal adhesion kinase--a regulator of cell migration and invasion

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12 December 2020

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

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12 December 2020

10.1023/B:JOMG.0000017427.14751.8C

Identifiers

DOI

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Dimensions Publication ID

9 August 2017

1041917022

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