Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice (Q35483789)

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10 February 2020

title

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice (English)

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10 February 2020

1 reference

10

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Mark D Fleming

11

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10 February 2020

1

Andrea U Steinbicker

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10 February 2020

author name string

Thomas B Bartnikas

2

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10 February 2020

Lisa K Lohmeyer

3

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10 February 2020

Patricio Leyton

4

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10 February 2020

Claire Mayeur

5

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10 February 2020

Sonya M Kao

6

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Alexandra E Pappas

7

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10 February 2020

Randall T Peterson

8

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10 February 2020

Donald B Bloch

9

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Kenneth D Bloch

12

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10 February 2020

language of work or name

English

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publication date

12 August 2011

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10 February 2020

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10 February 2020

volume

118

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issue

15

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10 February 2020

page(s)

4224-4230

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Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

10 February 2020

cites work

1 reference

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Iron overload induces BMP6 expression in the liver but not in the duodenum.

12 July 2018

1 reference

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Hepcidin in human iron disorders: therapeutic implications.

12 July 2018

1 reference

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BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice

12 July 2018

1 reference

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Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment

12 July 2018

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Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD.

12 July 2018

1 reference

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Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

12 July 2018

1 reference

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Hepcidin targets ferroportin for degradation in hepatocytes

12 July 2018

1 reference

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Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis

12 July 2018

1 reference

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Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis

12 July 2018

1 reference

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

12 July 2018

1 reference

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The regulation of hepcidin and its effects on systemic and cellular iron metabolism.

12 July 2018

1 reference

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204739

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204739

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

12 July 2018

1 reference

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The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease

12 July 2018

1 reference

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Restoration of liver mass after injury requires proliferative and not embryonic transcriptional patterns

12 July 2018

1 reference

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BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis

12 July 2018

1 reference

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204739

Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204739

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

12 July 2018

1 reference

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A mouse model of juvenile hemochromatosis

12 July 2018

1 reference

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Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

12 July 2018

1 reference

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Hepcidin in iron overload disorders

12 July 2018

1 reference

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204739

Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells

12 July 2018

1 reference

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Signal transduction of bone morphogenetic protein receptors

12 July 2018

1 reference

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Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

12 July 2018

1 reference

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Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

12 July 2018

1 reference

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

12 July 2018

1 reference

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Iron regulatory proteins and the molecular control of mammalian iron metabolism

12 July 2018

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Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis

12 July 2018

1 reference

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The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo

12 July 2018

1 reference

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HFE gene knockout produces mouse model of hereditary hemochromatosis

12 July 2018

1 reference

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Characterization of non-transferrin-bound iron clearance by rat liver

12 July 2018

1 reference

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BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.

12 July 2018

1 reference

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BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

26 September 2018

1 reference

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Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

26 September 2018

1 reference

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Generation of Bmpr/Alk3 conditional knockout mice.

26 September 2018

1 reference

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Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3204739

Proline-mediated enhancement of hepatocyte function in a collagen gel sandwich culture configuration

26 September 2018

1 reference

12 December 2020

HJV gene mutations in European patients with juvenile hemochromatosis

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12 December 2020

Pathology of hepatic iron overload

1 reference

12 December 2020

Anemia of inflammation

1 reference

12 December 2020

DNA excision in liver by an albumin-Cre transgene occurs progressively with age

1 reference

12 December 2020

10.1182/BLOOD-2011-03-339952

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21841161%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21841161%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

21841161

1 reference