Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design (Q35445886)

8 August 2017

title

Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design (English)

1 reference

8 August 2017

7

Amarnath Natarajan

1 reference

8 August 2017

Ziyan Yuan

1

1 reference

8 August 2017

Eric A Kumar

2

1 reference

8 August 2017

Stephen J Campbell

3

1 reference

8 August 2017

Nicholas Y Palermo

4

1 reference

8 August 2017

Smitha Kizhake

5

1 reference

8 August 2017

J N Mark Glover

6

1 reference

8 August 2017

publication date

1 October 2011

1 reference

ACS Medicinal Chemistry Letters

8 August 2017

published in

1 reference

8 August 2017

volume

2

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8 August 2017

issue

10

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8 August 2017

page(s)

764-767

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Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1.

8 August 2017

cites work

1 reference

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Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition

12 July 2018

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Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control

12 July 2018

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12 July 2018

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Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1

12 July 2018

1 reference

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Structural characterization of BRCT-tetrapeptide binding interactions.

12 July 2018

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12 July 2018

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Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

12 July 2018

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Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

12 July 2018

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

12 July 2018

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CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

12 July 2018

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

12 July 2018

1 reference

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A general framework for development and data analysis of competitive high-throughput screens for small-molecule inhibitors of protein-protein interactions by fluorescence polarization

12 July 2018

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The role of BRCA1 in the cellular response to chemotherapy

12 July 2018

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DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

12 July 2018

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Making optimal use of empirical energy functions: force-field parameterization in crystal space

12 July 2018

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Emerging classes of protein-protein interaction inhibitors and new tools for their development

12 July 2018

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Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

12 July 2018

1 reference

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Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

12 July 2018

1 reference

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

12 July 2018

1 reference

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The BRCT Domain Is a Phospho-Protein Binding Domain

12 July 2018

1 reference

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis

12 July 2018

1 reference

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Fluorescence polarization competition assay: the range of resolvable inhibitor potency is limited by the affinity of the fluorescent ligand

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

SH2 domain inhibition: a problem solved?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

12 July 2018

1 reference

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An exact correction to the "Cheng-Prusoff" correction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

High-throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Detection of protein folding defects caused by BRCA1-BRCT truncation and missense mutations

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3201719

Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor design

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22046493

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/ML200147A

1 reference

release_rb22dzlsu5dedcwligenfpnwbe

8 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rb22dzlsu5dedcwligenfpnwbe

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3201719

1 reference

8 August 2017

1 reference