p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases (Q35209995)

7 August 2017

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title

p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases (English)

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7 August 2017

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Sanjay Kumar

1

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7 August 2017

Jeffrey Boehm

series ordinal

2

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7 August 2017

John C Lee

series ordinal

3

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7 August 2017

publication date

1 September 2003

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Nature Reviews Drug Discovery

7 August 2017

published in

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7 August 2017

volume

2

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7 August 2017

issue

9

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7 August 2017

page(s)

717-726

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

7 August 2017

cites work

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

31 March 2020

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Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)

31 March 2020

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Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles

31 March 2020

1 reference

Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

31 March 2020

1 reference

The primary structure of p38 gamma: a new member of p38 group of MAP kinases

31 March 2020

1 reference

SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases

31 March 2020

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Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

31 March 2020

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Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3)

31 March 2020

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p38 MAP kinase: molecular target for the inhibition of pro-inflammatory cytokines.

31 March 2020

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Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

31 March 2020

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MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

31 March 2020

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MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein

31 March 2020

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A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs

31 March 2020

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MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases

31 March 2020

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Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells

31 March 2020

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MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

31 March 2020

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Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators

31 March 2020

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A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

31 March 2020

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The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism.

31 March 2020

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Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase

31 March 2020

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MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

31 March 2020

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p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

31 March 2020

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Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles. Isomeric 4-pyridyl and 4-substituted phenyl derivatives

31 March 2020

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Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002

31 March 2020

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p38 mitogen-activated protein kinase inhibitors--mechanisms and therapeutic potentials

31 March 2020

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Regulation of stress-induced cytokine production by pyridinylimidazoles; inhibition of CSBP kinase

31 March 2020

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Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.

31 March 2020

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1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency

31 March 2020

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Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity

31 March 2020

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Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase

31 March 2020

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Pyridinylimidazole based p38 MAP kinase inhibitors

31 March 2020

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The non-diaryl heterocycle classes of p38 MAP kinase inhibitors

31 March 2020

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Crystal structure of p38 mitogen-activated protein kinase

31 March 2020

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The structure of mitogen-activated protein kinase p38 at 2.1-A resolution

31 March 2020

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Structural basis of inhibitor selectivity in MAP kinases

31 March 2020

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The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

31 March 2020

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A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

31 March 2020

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Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

31 March 2020

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A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase

31 March 2020

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Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution

31 March 2020

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Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site

31 March 2020

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Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate

31 March 2020

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Differential effects of SB 242235, a selective p38 mitogen-activated protein kinase inhibitor, on IL-1 treated bovine and human cartilage/chondrocyte cultures

31 March 2020

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Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway

31 March 2020

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p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment

31 March 2020

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Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor type I in animal models of rheumatoid arthritis

31 March 2020

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Therapeutic strategies for rheumatoid arthritis

31 March 2020

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Inhibition of p38 mitogen-activated protein kinase decreases cardiomyocyte apoptosis and improves cardiac function after myocardial ischemia and reperfusion

31 March 2020

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Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis

31 March 2020

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SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors

31 March 2020

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The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

31 March 2020

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An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors

31 March 2020

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Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction

31 March 2020

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Pathways of inflammatory activation in Alzheimer's disease: potential targets for disease modifying drugs

31 March 2020

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FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38 mitogen-activated protein kinase

31 March 2020

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P38 mitogen-activated protein kinase inhibition attenuates ischemia-reperfusion injury of the rat liver

31 March 2020

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Sustained activation of p38 mitogen-activated protein kinase contributes to the vascular response to injury

31 March 2020

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p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease

31 March 2020

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Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers.

31 March 2020

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Coordinate activation of endogenous p38alpha, beta, gamma, and delta by inflammatory stimuli.

31 March 2020

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Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1177

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Dimensions Publication ID

7 August 2017

1052740573

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