Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling (Q35176374)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21694719%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling (English)

1 reference

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5 February 2020

0 references

1

1 reference

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5 February 2020

Janet Thornton

9

1 reference

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5 February 2020

Dan Andrews

2

1 reference

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5 February 2020

Irene Papatheodorou

4

1 reference

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5 February 2020

Cathy Slack

5

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5 February 2020

Eugene Schuster

8

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5 February 2020

Linda Partridge

10

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5 February 2020

author name string

Maria E Giannakou

3

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5 February 2020

Matthew P Hoddinott

6

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5 February 2020

Helena M Cochemé

7

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5 February 2020

publication date

21 June 2011

1 reference

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Molecular Systems Biology

5 February 2020

published in

1 reference

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5 February 2020

volume

7

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5 February 2020

page(s)

502

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describes a project that uses

5 February 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3159968

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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28 July 2018

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14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila

28 July 2018

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28 July 2018

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Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance.

28 July 2018

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FoxO transcription factors in the maintenance of cellular homeostasis during aging

28 July 2018

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Forkhead transcription factors and ageing

28 July 2018

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Drosophila lifespan control by dietary restriction independent of insulin-like signaling

28 July 2018

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PP2A regulates the pro-apoptotic activity of FOXO1.

28 July 2018

1 reference

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Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes

28 July 2018

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InParanoid 6: eukaryotic ortholog clusters with inparalogs

28 July 2018

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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

28 July 2018

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An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

28 July 2018

1 reference

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FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress

28 July 2018

1 reference

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Endocrine regulation of ageing

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

28 July 2018

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

28 July 2018

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Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells

28 July 2018

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28 July 2018

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MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis

28 July 2018

1 reference

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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span

28 July 2018

1 reference

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Transcriptional feedback control of insulin receptor by dFOXO/FOXO1.

28 July 2018

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Regulation of hunger-driven behaviors by neural ribosomal S6 kinase in Drosophila

28 July 2018

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JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling

28 July 2018

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

28 July 2018

1 reference

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Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

28 July 2018

1 reference

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Inparanoid: a comprehensive database of eukaryotic orthologs

28 July 2018

1 reference

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FlyBase: genes and gene models

28 July 2018

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Bioconductor: open software development for computational biology and bioinformatics

28 July 2018

1 reference

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The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

28 July 2018

1 reference

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Detection of functional DNA motifs via statistical over-representation

28 July 2018

1 reference

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Normalization of cDNA microarray data

28 July 2018

1 reference

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Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.

28 July 2018

1 reference

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Exploration, normalization, and summaries of high density oligonucleotide array probe level data

28 July 2018

1 reference

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The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

28 July 2018

1 reference

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Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

28 July 2018

1 reference

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

28 July 2018

1 reference

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DAVID: Database for Annotation, Visualization, and Integrated Discovery

28 July 2018

1 reference

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Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast

28 July 2018

1 reference

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A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

28 July 2018

1 reference

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TRANSFAC: transcriptional regulation, from patterns to profiles

28 July 2018

1 reference

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Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation.

28 July 2018

1 reference

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DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

A C. elegans mutant that lives twice as long as wild type

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Genes that regulate both development and longevity in Caenorhabditis elegans

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Purified Drosophila transcription factor, Adh distal factor-1 (Adf-1), binds to sites in several Drosophila promoters and activates transcription.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

dFOXO-independent effects of reduced insulin-like signaling in Drosophila

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice?

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

FOXO transcription factors in ageing and cancer.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Dynamics of the action of dFOXO on adult mortality in Drosophila

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Characterization of the Drosophila insulin receptor promoter.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Distinct genetic influences on locomotor senescence in Drosophila revealed by a series of metrical analyses

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

The DHR96 nuclear receptor regulates xenobiotic responses in Drosophila

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

TreeFam: a curated database of phylogenetic trees of animal gene families

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Insulin regulation of heart function in aging fruit flies

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Long-lived Drosophila with overexpressed dFOXO in adult fat body

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Summaries of Affymetrix GeneChip probe level data

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3159968

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMSB.2011.36

21 January 2018

Identifiers

DOI

10.1038/MSB.2011.36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21694719%20AND%20SRC:MED&resulttype=core&format=json

release_63gz45qsmnf2xjmhf7pu4lnrfq

5 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/63gz45qsmnf2xjmhf7pu4lnrfq

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21694719%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

21694719

1 reference