Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer (Q35150756)

6 August 2017

title

Niclosamide inhibits androgen receptor variants expression and overcomes enzalutamide resistance in castration-resistant prostate cancer (English)

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6 August 2017

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Chengfei Liu

1

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6 August 2017

Wei Lou

2

1 reference

6 August 2017

Yezi Zhu

3

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6 August 2017

Nagalakshmi Nadiminty

4

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6 August 2017

Chad T Schwartz

5

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6 August 2017

Christopher P Evans

6

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6 August 2017

Allen C Gao

7

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6 August 2017

language of work or name

English

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publication date

16 April 2014

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6 August 2017

published in

Clinical Cancer Research

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6 August 2017

volume

20

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6 August 2017

issue

12

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6 August 2017

page(s)

3198-3210

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Inhibition of protein kinase C/Twist1 signaling augments anticancer effects of androgen deprivation and enzalutamide in prostate cancer.

6 August 2017

cites work

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Inhibition of constitutively active Stat3 reverses enzalutamide resistance in LNCaP derivative prostate cancer cells

13 July 2018

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13 July 2018

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Inhibition of STAT3 by niclosamide synergizes with erlotinib against head and neck cancer

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Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer

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An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

13 July 2018

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A clinically relevant androgen receptor mutation confers resistance to second-generation antiandrogens enzalutamide and ARN-509.

13 July 2018

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13 July 2018

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NF-κB2/p52 induces resistance to enzalutamide in prostate cancer: role of androgen receptor and its variants

13 July 2018

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Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer

13 July 2018

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Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

13 July 2018

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13 July 2018

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13 July 2018

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Growth inhibition of ovarian tumor-initiating cells by niclosamide.

13 July 2018

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Androgen receptor directed therapies in castration-resistant metastatic prostate cancer

13 July 2018

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Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal

13 July 2018

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Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling

13 July 2018

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AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

13 July 2018

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Androgen receptor variants occur frequently in castration resistant prostate cancer metastases

13 July 2018

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Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: induction of steroidogenesis and androgen receptor splice variants

13 July 2018

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Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer

13 July 2018

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Novel Effect of Antihelminthic Niclosamide on S100A4-Mediated Metastatic Progression in Colon Cancer

13 July 2018

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Abiraterone and increased survival in metastatic prostate cancer

13 July 2018

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Expression of Androgen Receptor Splice Variants in Prostate Cancer Bone Metastases is Associated with Castration-Resistance and Short Survival

13 July 2018

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Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations

13 July 2018

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A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities

13 July 2018

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Intragenic Rearrangement and Altered RNA Splicing of the Androgen Receptor in a Cell-Based Model of Prostate Cancer Progression

13 July 2018

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Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

13 July 2018

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Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

13 July 2018

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Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study

13 July 2018

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13 July 2018

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Interleukin-6 regulates androgen synthesis in prostate cancer cells

13 July 2018

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A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058390

Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer

13 July 2018

1 reference

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Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058390

Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line

13 July 2018

1 reference

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Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular Localization

13 July 2018

1 reference

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Words of wisdom. Re: androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058390

Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058390

Hymenolepis diminuta: mitochondrial transhydrogenase as an additional site for anaerobic phosphorylation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058390

In vitro trypanocidal activity of the anti-helminthic drug niclosamide

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058390

Basic fibroblast growth factor levels in cancer cells and in sera of patients suffering from proliferative disorders of the prostate

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24740322

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1078-0432.CCR-13-3296

1 reference

release_vuff3ogggngxpn4k6nf4lrgdie

6 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vuff3ogggngxpn4k6nf4lrgdie

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

4058390

1 reference

6 August 2017

1 reference