Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2) (Q35107372)

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1 February 2020

title

Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2) (English)

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1 February 2020

1

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1 February 2020

Michel Bouvier

8

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1 February 2020

author name string

Koichiro Mihara

2

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1 February 2020

Hyunjae Chung

3

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1 February 2020

Bernard Renaux

4

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1 February 2020

Chang S Lau

5

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1 February 2020

Daniel A Muruve

6

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1 February 2020

Kathryn A DeFea

7

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Morley D Hollenberg

9

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language of work or name

English

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publication date

16 May 2011

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Journal of Biological Chemistry

1 February 2020

published in

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volume

286

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issue

28

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page(s)

24638-24648

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Structure, function and pathophysiology of protease activated receptors.

1 February 2020

cites work

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PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology

9 July 2018

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Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling.

9 July 2018

1 reference

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Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways.

9 July 2018

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Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site

9 July 2018

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Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway

9 July 2018

1 reference

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Neutrophil-derived serine proteases modulate innate immune responses.

9 July 2018

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Neutrophil-mediated activation of epithelial protease-activated receptors-1 and -2 regulates barrier function and transepithelial migration

9 July 2018

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Protease-activated receptor-2 exerts contrasting model-specific effects on acute experimental pancreatitis

9 July 2018

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Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin

9 July 2018

1 reference

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Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more.

9 July 2018

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Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction

9 July 2018

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Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.

9 July 2018

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Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

9 July 2018

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Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2.

9 July 2018

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Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion

9 July 2018

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Proteinase-activated receptors, targets for kallikrein signaling

9 July 2018

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Protease-activated receptors in hemostasis, thrombosis and vascular biology

9 July 2018

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A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis

9 July 2018

1 reference

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Proteinase-activated receptor-1 mediates elastase-induced apoptosis of human lung epithelial cells

9 July 2018

1 reference

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Clinical relevance of proteinase activated receptors (pars) in the gut

9 July 2018

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Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells.

9 July 2018

1 reference

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Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking

9 July 2018

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Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.

9 July 2018

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9 July 2018

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Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis

9 July 2018

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Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry.

9 July 2018

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

9 July 2018

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Cathepsin G activates protease-activated receptor-4 in human platelets

9 July 2018

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9 July 2018

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

9 July 2018

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Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.

9 July 2018

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Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.

27 September 2018

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Mammalian cell-based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity

27 September 2018

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Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

27 September 2018

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Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling

27 September 2018

1 reference

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Proteinase-activated receptor-2: key role of amino-terminal dipeptide residues of the tethered ligand for receptor activation

27 September 2018

1 reference

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The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137039

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization

27 September 2018

1 reference

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Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands

27 September 2018

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12 December 2020

A protective role for protease-activated receptors in the airways

1 reference

12 December 2020

The characterization of alpha5-integrin expression on tubular epithelium during renal injury

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12 December 2020

Proinflammatory and proliferative responses of human proximal tubule cells to PAR-2 activation

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.201988

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21576245%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

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1 February 2020

PubMed publication ID

21576245

1 reference