Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis (Q35073171)

6 August 2017

title

Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis (English)

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6 August 2017

Bingning Dong

1

1 reference

6 August 2017

Ju-Seog Lee

2

1 reference

6 August 2017

Yun-Yong Park

3

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6 August 2017

Feng Yang

4

1 reference

6 August 2017

Ganyu Xu

5

1 reference

6 August 2017

Wendong Huang

6

1 reference

6 August 2017

Milton J Finegold

7

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6 August 2017

David D Moore

8

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6 August 2017

language of work or name

English

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publication date

9 February 2015

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6 August 2017

published in

Nature Communications

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6 August 2017

volume

6

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6 August 2017

page(s)

5944

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Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?

6 August 2017

cites work

1 reference

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8 July 2018

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Structural basis of coactivation of liver receptor homolog-1 by -catenin

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Wnt/β-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway

8 July 2018

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Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

8 July 2018

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CKIα ablation highlights a critical role for p53 in invasiveness control

8 July 2018

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8 July 2018

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8 July 2018

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FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance

8 July 2018

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Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro

8 July 2018

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Role of Wnt/β-catenin signaling in liver metabolism and cancer

8 July 2018

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8 July 2018

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8 July 2018

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FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression.

8 July 2018

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Augmented Wnt signaling in a mammalian model of accelerated aging

8 July 2018

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Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.

8 July 2018

1 reference

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

8 July 2018

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A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment

8 July 2018

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Genetics of hepatocellular tumors.

8 July 2018

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Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase

8 July 2018

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Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor

8 July 2018

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8 July 2018

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8 July 2018

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

8 July 2018

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8 July 2018

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8 July 2018

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Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

8 July 2018

1 reference

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

8 July 2018

1 reference

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Identification of c-MYC as a target of the APC pathway

8 July 2018

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Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Hepatocellular carcinoma development induced by conditional beta-catenin activation in Lkb1+/- mice.

27 September 2018

1 reference

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C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Skp2-mediated degradation of p27 regulates progression into mitosis

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Lack of tumorigenesis in the mouse liver after adenovirus-mediated expression of a dominant stable mutant of beta-catenin.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.

27 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS6944

Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS6944

T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324535

Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma

27 September 2018

1 reference

12 December 2020

Phenotype of single hepatocytes expressing an activated version of β-catenin in liver of transgenic mice

1 reference

12 December 2020

Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations

1 reference

12 December 2020

Hepatomegaly in transgenic mice expressing an oncogenic form of beta-catenin

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS6944

1 reference

Dimensions Publication ID

6 August 2017

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6 August 2017

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