Mitochondria: releasing power for life and unleashing the machineries of death (Q35071387)

6 August 2017

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title

Mitochondria: releasing power for life and unleashing the machineries of death (English)

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6 August 2017

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Donald D Newmeyer

1

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6 August 2017

Shelagh Ferguson-Miller

series ordinal

2

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6 August 2017

language of work or name

English

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publication date

1 February 2003

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6 August 2017

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6 August 2017

volume

112

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6 August 2017

issue

4

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6 August 2017

page(s)

481-490

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Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

6 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis

1 reference

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7 January 2021

Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes

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7 January 2021

Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

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7 January 2021

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

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7 January 2021

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

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7 January 2021

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

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7 January 2021

Early mitochondrial activation and cytochrome c up-regulation during apoptosis

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7 January 2021

tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane

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7 January 2021

Ultrastructural localization of cytochrome c in apoptosis demonstrates mitochondrial heterogeneity.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The permeability transition pore signals apoptosis by directing Bax translocation and multimerization.

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7 January 2021

Lipids, cardiolipin and apoptosis: a greasy licence to kill

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7 January 2021

Sequence and functional similarities between pro-apoptotic Bid and plant lipid transfer proteins

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The apoptotic protein tBid promotes leakage by altering membrane curvature

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Membrane perturbations induced by the apoptotic Bax protein

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Direct evidence for membrane pore formation by the apoptotic protein Bax

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

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7 January 2021

Mitochondrial reactive oxygen species in cell death signaling

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7 January 2021

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

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7 January 2021

A matter of life and death

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The harlequin mouse mutation downregulates apoptosis-inducing factor

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondrial transmembrane potential changes support the concept of mitochondrial heterogeneity during apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Role of mitochondria in oxidative stress and aging

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Generation of reactive oxygen species by the mitochondrial electron transport chain

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Cardiolipin provides specificity for targeting of tBid to mitochondria

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondria and calcium homeostasis: a tale of three luminescent proteins

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7 January 2021

Mitochondrial permeability transition is a central coordinating event of apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondrial disease in superoxide dismutase 2 mutant mice

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondrial phospholipid hydroperoxide glutathione peroxidase inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Organelle fission in eukaryotes

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The Overexpression of Bax Produces Cell Death upon Induction of the Mitochondrial Permeability Transition

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The comeback of mitochondria to calcium signalling

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Cytosolic Ca(2+) signal is involved in regulating UV-induced apoptosis in hela cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondria as biosensors of calcium microdomains

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondria as all-round players of the calcium game

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bid induces cytochrome c-impermeable Bax channels in liposomes

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondrial superoxide radical formation is controlled by electron bifurcation to the high and low potential pathways

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Apoptosis driven by IP(3)-linked mitochondrial calcium signals

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

BMD188, A novel hydroxamic acid compound, demonstrates potent anti-prostate cancer effects in vitro and in vivo by inducing apoptosis: requirements for mitochondria, reactive oxygen species, and proteases

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Redox control of cell death

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Mitochondrial diseases in man and mouse

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Merging mitochondria matters: cellular role and molecular machinery of mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

The mitochondrion in apoptosis: how Pandora's box opens

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

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https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2803%2900116-8

7 January 2021

10.1016/S0092-8674(03)00116-8

Identifiers

DOI

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6 August 2017

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