Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates. (Q35047056)

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16 December 2019

review article

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title

Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates (English)

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16 December 2019

1

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16 December 2019

author name string

Youri I Pavlov

series ordinal

2

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16 December 2019

Katarzyna Bebenek

series ordinal

3

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16 December 2019

publication date

1 February 2003

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16 December 2019

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16 December 2019

volume

2

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16 December 2019

issue

2

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16 December 2019

page(s)

135-149

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The Y-family of DNA polymerases

16 December 2019

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Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).

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Misinsertion and bypass of thymine-thymine dimers by human DNA polymerase iota

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Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

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Preferential incorporation of G opposite template T by the low-fidelity human DNA polymerase iota

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Translesion synthesis by yeast DNA polymerase zeta from templates containing lesions of ultraviolet radiation and acetylaminofluorene

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Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.

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Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

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DNA lesion bypass polymerases open up.

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A reexamination of the nucleotide incorporation fidelity of DNA polymerases

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Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication

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Low fidelity DNA synthesis by human DNA polymerase-eta

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Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro

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7 January 2021

Fidelity of human DNA polymerase eta

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Translesion synthesis by human DNA polymerase eta across thymine glycol lesions

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Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally

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7 January 2021

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7 January 2021

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7 January 2021

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Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

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AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

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7 January 2021

The AID enzyme induces class switch recombination in fibroblasts

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AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

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Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

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A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes

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7 January 2021

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7 January 2021

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Identifiers

DOI

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16 December 2019

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