Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection. (Q35021753)

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English	Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection.	scientific article

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28 February 2020

Activation associated ERK1/2 signaling impairments in CD8+ T cells co-localize with blunted polyclonal and HIV-1 specific effector functions in early untreated HIV-1 infection (English)

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28 February 2020

Frederick M. Hecht

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28 February 2020

Lishomwa Ndhlovu

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28 February 2020

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Timothy Q Crawford

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28 February 2020

Christopher D Pilcher

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28 February 2020

Jason D Barbour

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28 February 2020

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15 October 2013

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28 February 2020

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28 February 2020

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28 February 2020

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28 February 2020

e77412

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28 February 2020

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15 October 2013

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Intrinsic role of FoxO3a in the development of CD8+ T cell memory

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Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection

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Tuberculosis and HIV co-infection

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FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms.

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HIV-1 infection abrogates CD8+ T cell mitogen-activated protein kinase signaling responses.

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Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy

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8 July 2018

T cell exhaustion

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8 July 2018

Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control

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HIV-associated immune activation: from bench to bedside

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8 July 2018

Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression

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8 July 2018

Signaling through the P38 and ERK pathways: a common link between HIV replication and the immune response.

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8 July 2018

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control

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8 July 2018

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells

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8 July 2018

ERK and cell death: ERK location and T cell selection

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8 July 2018

Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.

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8 July 2018

A critical role for CD8 T cells in a nonhuman primate model of tuberculosis

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8 July 2018

High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication

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8 July 2018

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

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8 July 2018

The Erk2 MAPK regulates CD8 T cell proliferation and survival

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8 July 2018

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

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8 July 2018

The cytolytic enzymes granyzme A, granzyme B, and perforin: expression patterns, cell distribution, and their relationship to cell maturity and bright CD57 expression

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8 July 2018

CREB, ATF, and AP-1 transcription factors regulate IFN-gamma secretion by human T cells in response to mycobacterial antigen

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8 July 2018

HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control

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8 July 2018

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

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8 July 2018

Scaffold proteins of MAP-kinase modules.

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Accelerated immune senescence and HIV-1 infection

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8 July 2018

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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Inhibition of IFN-gamma transcription by site-specific methylation during T helper cell development

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

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CD8+ T cells in tuberculosis

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8 July 2018

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

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21 January 2018

Differential upregulation of CD38 on different T-cell subsets may influence the ability to reconstitute CD4+ T cells under successful highly active antiretroviral therapy

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21 January 2018

The role of erk1 and erk2 in multiple stages of T cell development

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21 January 2018

Performance characteristics of a new less sensitive HIV-1 enzyme immunoassay for use in estimating HIV seroincidence

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21 January 2018

Phenotypic classification of human CD8+ T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function

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21 January 2018

Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells

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21 January 2018

Epigenetic remodeling of the IL-2 and IFN-gamma loci in memory CD8 T cells is influenced by CD4 T cells.

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21 January 2018

A mechanism underlying STAT4-mediated up-regulation of IFN-gamma induction inTCR-triggered T cells.

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21 January 2018

Skewed maturation of memory HIV-specific CD8 T lymphocytes

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21 January 2018

Activation of the extracellular signal-regulated kinase pathway is differentially required for TCR-stimulated production of six cytokines in primary T lymphocytes

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21 January 2018

Differential activation of T cell cytokine production by the extracellular signal-regulated kinase (ERK) signaling pathway

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21 January 2018

HIV Controllers Are Distinguished by Chemokine Expression Profile and HIV-Specific T-Cell Proliferative Potential

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21 January 2018

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

1 reference

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21 January 2018

The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/24143233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune activation and antibody responses in non-progressing elite controller individuals infected with HIV-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/24143233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24143233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV Gag p24 specific responses secreting IFN-gamma and/or IL-2 in treatment-naïve individuals in acute infection early disease (AIED) are associated with low viral load

1 reference

https://pubmed.ncbi.nlm.nih.gov/24143233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24143233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/24143233

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0077412

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28 February 2020

2013PLoSO...877412C

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28 February 2020

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28 February 2020

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