RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation (Q35005658)

5 August 2017

title

RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation (English)

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5 August 2017

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Joanna Doumanis

1

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5 August 2017

Koji Wada

2

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5 August 2017

Yoshihiro Kino

3

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5 August 2017

Adrian W Moore

4

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5 August 2017

Nobuyuki Nukina

5

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5 August 2017

language of work or name

English

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publication date

30 September 2009

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5 August 2017

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5 August 2017

volume

4

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5 August 2017

issue

9

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5 August 2017

page(s)

e7275

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Creative Commons Attribution 4.0 International

5 August 2017

copyright license

start time

30 September 2009

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2748703/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Mechanisms of neurodegeneration in Huntington's disease.

1 reference

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RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748703

Design and implementation of high-throughput RNAi screens in cultured Drosophila cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748703

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748703

A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila

8 July 2018

1 reference

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Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays

8 July 2018

1 reference

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Prevalence of off-target effects in Drosophila RNA interference screens

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748703

Biologically active molecules that reduce polyglutamine aggregation and toxicity

8 July 2018

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Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases

8 July 2018

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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

8 July 2018

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Drosophila models of neurodegenerative disease

8 July 2018

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Drosophila as a model for human neurodegenerative disease

8 July 2018

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Drosophila: a "model" model system to study neurodegeneration

8 July 2018

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E-RNAi: a web application to design optimized RNAi constructs

8 July 2018

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Polyglutamine expansion of huntingtin impairs its nuclear export

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2748703

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

8 July 2018

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

8 July 2018

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Can flies help humans treat neurodegenerative diseases?

8 July 2018

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Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

8 July 2018

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Calmodulin-dependent and -independent apoptosis in cell of a Drosophila neuronal cell line

8 July 2018

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Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

8 July 2018

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Genetic suppression of polyglutamine toxicity in Drosophila

8 July 2018

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RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila.

8 July 2018

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Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007275

RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0007275

10.1371/JOURNAL.PONE.0007275

21 January 2018

Identifiers

DOI

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5 August 2017

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5 August 2017

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