Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone). (Q35001430)

5 August 2017

title

Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone). (English)

1 reference

5 August 2017

5

Yves Pommier

1 reference

5 August 2017

Chi Chen

1

1 reference

5 August 2017

Linghua Meng

2

1 reference

5 August 2017

Xiaochao Ma

3

1 reference

5 August 2017

Kristopher W Krausz

4

1 reference

5 August 2017

Jeffrey R Idle

6

1 reference

5 August 2017

Frank J Gonzalez

7

1 reference

5 August 2017

language of work or name

English

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publication date

14 June 2006

1 reference

Journal of Pharmacology and Experimental Therapeutics

5 August 2017

published in

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5 August 2017

volume

318

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5 August 2017

issue

3

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5 August 2017

page(s)

1330-1342

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Activation of aminoflavone (NSC 686288) by a sulfotransferase is required for the antiproliferative effect of the drug and for induction of histone gamma-H2AX.

5 August 2017

cites work

1 reference

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CYP1A1 activation of aminoflavone leads to DNA damage in human tumor cell lines

8 July 2018

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DNA-protein cross-links and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against human breast cancer cells

8 July 2018

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Aryl hydrocarbon receptor activation of an antitumor aminoflavone: basis of selective toxicity for MCF-7 breast tumor cells.

8 July 2018

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8 July 2018

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Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.

8 July 2018

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Structure-activity relationships of the 7-substituents of 5,4'-diamino-6,8,3'-trifluoroflavone, a potent antitumor agent

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.

8 July 2018

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8 July 2018

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8 July 2018

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Fast-atom bombardment and electron-impact mass spectrometry of N-hydroxyarylamines, active intermediates of mutagenic aromatic amines

8 July 2018

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Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

8 July 2018

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8 July 2018

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8 July 2018

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Sensitivity of renal cell carcinoma to aminoflavone: role of CYP1A1.

26 October 2018

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26 October 2018

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Determination of flavonol metabolites in plasma and tissues of rats by HPLC-radiocounting and tandem mass spectrometry following oral ingestion of [2-(14)C]quercetin-4'-glucoside.

26 October 2018

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26 October 2018

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Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9.

26 October 2018

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Identification of the principal circulating metabolite of a synthetic 5,4'-diaminoflavone (NSC 686288), an antitumor agent, in the rat.

26 October 2018

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Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16775196

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

CYP2C9 is a principal low-affinity phenacetin O-deethylase: fluvoxamine is not a specific CYP1A2 inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16775196

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/JPET.106.105213

1 reference

5 August 2017

1 reference

5 August 2017

1 reference