HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses (Q34999383)

5 August 2017

title

HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses (English)

1 reference

5 August 2017

1 reference

Katherine L Nathanson

8

object named as

Katherine L Nathanson

1 reference

5 August 2017

Jessica A Bertout

1

1 reference

5 August 2017

Amar J Majmundar

2

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5 August 2017

John D Gordan

3

1 reference

5 August 2017

Jennifer C Lam

4

1 reference

5 August 2017

Dara Ditsworth

5

1 reference

5 August 2017

Brian Keith

6

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5 August 2017

Eric J Brown

7

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5 August 2017

M Celeste Simon

9

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5 August 2017

language of work or name

English

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publication date

12 August 2009

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

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5 August 2017

volume

106

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5 August 2017

issue

34

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5 August 2017

page(s)

14391-14396

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Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing

5 August 2017

cites work

1 reference

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HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

8 July 2018

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The impact of O2 availability on human cancer

8 July 2018

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p53 Binding to the p21 promoter is dependent on the nature of DNA damage

8 July 2018

1 reference

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Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Hypoxia-inducible factors: central regulators of the tumor phenotype

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Outcomes of p53 activation--spoilt for choice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Inhibiting hypoxia-inducible factor 1 for cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

p53 stabilization and transactivation by a von Hippel-Lindau protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

The complexity of p53 stabilization and activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Expression of p53 in renal carcinoma cells is independent of pVHL.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Binding of natively unfolded HIF-1alpha ODD domain to p53

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Targeting HIF-1 for cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Heme oxygenase-1: unleashing the protective properties of heme

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Regulation of angiogenesis by hypoxia: role of the HIF system

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage

8 July 2018

1 reference

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Tissue-specific induction of p53 targets in vivo.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726037

p53 pathway in renal cell carcinoma is repressed by a dominant mechanism.

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907357106

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907357106

Genetic evidence for a tumor suppressor role of HIF-2alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907357106

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0907357106

Direct evidence of caeruloplasmin antioxidant properties

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19706526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

XIAP regulates intracellular ROS by enhancing antioxidant gene expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19706526

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0907357106

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference