Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease (Q34901262)

5 August 2017

title

Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease (English)

1 reference

5 August 2017

0 references

1 reference

GOA release 2020-03-11

H15 Dmel_CG6604

1 reference

GOA release 2020-03-11

6

Jeffrey A Towbin

1 reference

5 August 2017

Li Qian

1

1 reference

5 August 2017

Bhagyalaxmi Mohapatra

2

1 reference

5 August 2017

Takeshi Akasaka

3

1 reference

5 August 2017

Jiandong Liu

4

1 reference

5 August 2017

Karen Ocorr

5

1 reference

5 August 2017

Rolf Bodmer

7

1 reference

5 August 2017

language of work or name

English

0 references

publication date

11 December 2008

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

published in

1 reference

5 August 2017

volume

105

1 reference

5 August 2017

issue

50

1 reference

5 August 2017

page(s)

19833-19838

1 reference

Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype

5 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Penetrance of mutations in plakophilin-2 among families with arrhythmogenic right ventricular dysplasia/cardiomyopathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Drosophila as a model for the identification of genes causing adult human heart disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Drosophila, an emerging model for cardiac disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Differential expression and function of Tbx5 and Tbx20 in cardiac development

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Early signals in cardiac development.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Developmental paradigms in heart disease: insights from tinman

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Control of cardiac development by an evolutionarily conserved transcriptional network

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Modelling neurodegenerative diseases in Drosophila: a fruitful approach?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

The "final common pathway" hypothesis and inherited cardiovascular disease. The role of cytoskeletal proteins in dilated cardiomyopathy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

A Drosophila model of Parkinson's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Congenital heart disease caused by mutations in the transcription factor NKX2-5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

The gene tinman is required for specification of the heart and visceral muscles in Drosophila

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Characterization of components of Z-bands in the fibrillar flight muscle of Drosophila melanogaster

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Insulin regulation of heart function in aging fruit flies

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Ostia, the inflow tracts of the Drosophila heart, develop from a genetically distinct subset of cardial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

The T-box-encoding Dorsocross genes function in amnioserosa development and the patterning of the dorsolateral germ band downstream of Dpp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesoderm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Drosophila MEF2, a transcription factor that is essential for myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0808705105

Screening assays for heart function mutants in Drosophila.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2605007

Low penetrance in the long-QT syndrome: clinical impact

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19074289

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0808705105

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference