Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus (Q34897437)

5 August 2017

title

Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus (English)

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systemic lupus erythematosus

5 August 2017

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inferred from title

author

Gerd-Rüdiger Burmester

6

object named as

Gerd R Burmester

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5 August 2017

Thomas Dörner

1

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5 August 2017

Joerg Kaufmann

2

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5 August 2017

William A Wegener

3

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5 August 2017

Nick Teoh

4

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5 August 2017

David M Goldenberg

5

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5 August 2017

publication date

21 April 2006

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Arthritis Research and Therapy

5 August 2017

published in

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5 August 2017

volume

8

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5 August 2017

issue

3

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5 August 2017

page(s)

R74

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Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future

5 August 2017

cites work

1 reference

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8 July 2018

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Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions.

8 July 2018

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Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties

8 July 2018

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From BILAG to BLIPS--disease activity assessment in lupus past, present and future

8 July 2018

1 reference

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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux

8 July 2018

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A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus

8 July 2018

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Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies

8 July 2018

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CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor

8 July 2018

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B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines

8 July 2018

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Lupus-specific antibodies reveal an altered pattern of somatic mutation

8 July 2018

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8 July 2018

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CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling.

8 July 2018

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CD22 is a negative regulator of B-cell receptor signalling

8 July 2018

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CD22 regulates thymus-independent responses and the lifespan of B cells.

8 July 2018

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Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2.

8 July 2018

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CD22, a B cell-specific receptor, mediates adhesion and signal transduction.

8 July 2018

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Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype

8 July 2018

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The BILAG index: a reliable and valid instrument for measuring clinical disease activity in systemic lupus erythematosus.

8 July 2018

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The role of B cells in lpr/lpr-induced autoimmunity

8 July 2018

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Epitope specificity of the anti-(B cell lymphoma) monoclonal antibody, LL2

8 July 2018

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The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.

8 July 2018

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The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22.

8 July 2018

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Regulation of CD45 engagement by the B-cell receptor CD22.

8 July 2018

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Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily

8 July 2018

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Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor

8 July 2018

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Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains

8 July 2018

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Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lymphoma: phase I/II clinical trial results.

8 July 2018

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CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity

26 October 2018

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Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus

26 October 2018

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An open study of B lymphocyte depletion in systemic lupus erythematosus

26 October 2018

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Production of pathogenic antibodies: cognate interactions between autoimmune T and B cells.

26 October 2018

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A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice.

26 October 2018

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Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma

26 October 2018

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12 December 2020

B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab

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12 December 2020

Two new monoclonal antibodies, EPB-1 and EPB-2, reactive with human lymphoma

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12 December 2020

Association of CD22 with the B cell antigen receptor

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12 December 2020

Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus

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12 December 2020

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12 December 2020

B lymphocytes as autoantigen-presenting cells in the amplification of autoimmunity

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12 December 2020

Anti-CD20 therapy in systemic lupus erythematosus: a step closer to the clinic

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12 December 2020

Breakdown of Tolerance to a Neo-Self Antigen in Double Transgenic Mice in Which B Cells Present the Antigen

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12 December 2020

Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus

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12 December 2020

Identifiers

DOI

10.1186/AR1942

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Dimensions Publication ID

5 August 2017

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5 August 2017

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