Access roads for RAG-ged terrains: control of T cell receptor gene rearrangement at multiple levels (Q34831667)

4 August 2017

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title

Access roads for RAG-ged terrains: control of T cell receptor gene rearrangement at multiple levels (English)

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4 August 2017

Ferenc Livák

1

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4 August 2017

Howard T Petrie

series ordinal

2

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4 August 2017

publication date

1 October 2002

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4 August 2017

published in

Seminars in Immunology

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4 August 2017

volume

14

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4 August 2017

issue

5

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4 August 2017

page(s)

297-309

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Selecting and maintaining a diverse T-cell repertoire

4 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

V(D)J recombination: on the cutting edge

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Antigen receptor gene rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Mice lacking TdT: mature animals with an immature lymphocyte repertoire

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

T cell receptor gene diversity and selection

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

V(D)J recombination: a functional definition of the joining signals

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Development and selection of gamma delta T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

In-frame TCR delta gene rearrangements play a critical role in the alpha beta/gamma delta T cell lineage decision

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Control of gamma delta T-cell development.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Receptors and signals in early thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Hypothesis: genes which function in a stochastic lineage commitment process are subject to monoallelic expression

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The somatic generation of immune recognition

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Structure and function of the pre-T cell receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

V(D)J recombination and the cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The human gamma/delta + and alpha/beta + T cells: a branched pathway of differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Self-reactive gamma delta T cells are eliminated in the thymus

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Assembly of productive T cell receptor delta variable region genes exhibits allelic inclusion

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Expression of two T cell receptor alpha chains: dual receptor T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Allelic inclusion of T cell receptor alpha genes poses an autoimmune hazard due to low-level expression of autospecific receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Both TCR alpha and TCR delta chain diversity are regulated during thymic ontogeny.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Developmentally regulated and lineage-specific rearrangement of T cell receptor Vα/δ gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Genetic modulation of T cell receptor gene segment usage during somatic recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Biased V beta usage in immature thymocytes is independent of DJ beta proximity and pT alpha pairing.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Somatic generation of antigen-receptor diversity: a reprise

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Mechanisms that direct ordered assembly of T cell receptor beta locus V, D, and J gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Developmentally controlled and tissue-specific expression of unrearranged VH gene segments

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Factors and forces controlling V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Accessibility and the developmental regulation of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Unequal access: regulating V(D)J recombination through chromatin remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

V(D)J recombination becomes accessible

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Developmental regulation of TCR delta locus accessibility and expression by the TCR delta enhancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Function of the TCR alpha enhancer in alphabeta and gammadelta T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

A targeted mutation at the T-cell receptor alpha/delta locus impairs T-cell development and reveals the presence of the nearby antiapoptosis gene Dad1.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Evidence for recombinatorial hot spots at the T cell receptor Jα locus

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

A role for histone acetylation in the developmental regulation of VDJ recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Histone acetylation and transcriptional regulatory mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Stimulation of V(D)J recombination by histone acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Histone acetylation and hSWI/SNF remodeling act in concert to stimulate V(D)J cleavage of nucleosomal DNA

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Chromatin remodeling directly activates V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Translating the Histone Code

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Alternative splicing of rearranged T cell receptor delta sequences to the constant region of the alpha locus

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Deletion of germline promoter PD beta 1 from the TCR beta locus causes hypermethylation that impairs D beta 1 recombination by multiple mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Distinct control of the frequency and allelic exclusion of the V beta gene rearrangement at the TCR beta locus

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Blockage of alpha beta T-cell development by TCR gamma delta transgenes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Developmentally programmed rearrangement of T cell receptor Vgamma genes is controlled by sequences immediately upstream of the Vgamma genes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Positive and negative regulation of V(D)J recombination by the E2A proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Induction of a diverse T cell receptor gamma/delta repertoire by the helix-loop-helix proteins E2A and HEB in nonlymphoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The IL-7 receptor controls the accessibility of the TCRgamma locus by Stat5 and histone acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

V(D)J recombination signal recognition: distinct, overlapping DNA-protein contacts in complexes containing RAG1 with and without RAG2.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Coding end sequence can markedly affect the initiation of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Conservation of sequence in recombination signal sequence spacers

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Comparative genomics of the human and mouse T cell receptor loci

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1044-5323%2802%2900063-5

7 January 2021

10.1016/S1044-5323(02)00063-5

Identifiers

DOI

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4 August 2017

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