Loss of p53 and centrosome hyperamplification. (Q34818333)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12214254%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

review article

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title

Loss of p53 and centrosome hyperamplification (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12214254%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

1

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12 November 2019

author name string

Kenji Fukasawa

series ordinal

2

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12 November 2019

language of work or name

English

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publication date

1 September 2002

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12 November 2019

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12 November 2019

volume

21

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12 November 2019

issue

40

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12 November 2019

page(s)

6234-6240

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Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells

12 November 2019

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c-abl is involved in the association of p53 and trk A.

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Both viral (adenovirus E1B) and cellular (hsp 70, p53) components interact with centrosomes.

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Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression.

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p53 displacement from centrosomes and p53-mediated G1 arrest following transient inhibition of the mitotic spindle.

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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Accumulation of cyclin E is not a prerequisite for passage through the restriction point

21 January 2018

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Abnormal centrosome amplification in the absence of p53.

21 January 2018

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Cdk inhibitors in development and cancer

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Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

21 January 2018

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p53 mutations in human cancers

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Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: implications for genotoxicity testing

21 January 2018

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Tumor spectrum analysis in p53-mutant mice

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Microtubule organizing centers and gamma-tubulin

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p53: puzzle and paradigm

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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

21 January 2018

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Regulation of p53 stability by Mdm2

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Cyclin-dependent kinase control of centrosome duplication

21 January 2018

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p53: oncogene or anti-oncogene?

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Cloning and characterization of Chinese hamster p53 cDNA.

21 January 2018

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Genetic instability in colorectal cancers

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The p53 tumour suppressor gene

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Centrosome amplification drives chromosomal instability in breast tumor development

21 January 2018

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High metastatic potential in mice inheriting a targeted p53 missense mutation

21 January 2018

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Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells

21 January 2018

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

21 January 2018

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p53 Expression in normal versus transformed mammalian cells

21 January 2018

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p53 localizes to the centrosomes and spindles of mitotic cells in the embryonic chick epiblast, human cell lines, and a human primary culture: An immunofluorescence study

21 January 2018

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A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model

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Cyclin-dependent regulation of G1 in mammalian fibroblasts.

21 January 2018

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

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G1 phase progression: cycling on cue

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway

21 January 2018

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Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53.

21 January 2018

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Distinct roles for cyclin-dependent kinases in cell cycle control

21 January 2018

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Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis

21 January 2018

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Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations

21 January 2018

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Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

21 January 2018

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7 January 2021

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

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7 January 2021

Association of human cyclin E with a periodic G1-S phase protein kinase

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7 January 2021

Genomic instability and apoptosis are frequent in p53 deficient young mice

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7 January 2021

Rules to replicate by

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7 January 2021

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

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7 January 2021

Ordering S phase and M phase in the cell cycle

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7 January 2021

Effect of p53 on centrosome amplification in prostate cancer cells

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7 January 2021

Treatment of periorbital wrinkles. A comparison of the SilkTouch carbon dioxide laser with a medium-depth chemical peel

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7 January 2021

Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205707

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12214254%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 November 2019

1046883420

0 references

1 reference