The role of BRCA1 in DNA damage response (Q34807044)

4 August 2017

1 reference

title

The role of BRCA1 in DNA damage response (English)

1 reference

4 August 2017

0 references

Jiaxue Wu

1

1 reference

4 August 2017

Lin-Yu Lu

series ordinal

2

1 reference

4 August 2017

Xiaochun Yu

series ordinal

3

1 reference

4 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21203981

21 November 2024

publication date

1 February 2010

1 reference

4 August 2017

February 2010

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21203981

full work available at URL

21 November 2024

https://academic.oup.com/proteincell/article-pdf/1/2/117/48344348/13238_2010_article_10.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21203981

https://europepmc.org/articles/PMC3078634

21 November 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21203981

https://europepmc.org/articles/PMC3078634?pdf=render

21 November 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21203981

https://doi.org/10.1007/s13238-010-0010-5

21 November 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21203981

http://link.springer.com/content/pdf/10.1007/s13238-010-0010-5.pdf

21 November 2024

file format

Portable Document Format

1 reference

DOI

https://api.crossref.org/works/10.1007/S13238-010-0010-5

http://link.springer.com/article/10.1007/s13238-010-0010-5/fulltext.html

21 November 2024

1 reference

https://api.crossref.org/works/10.1007/S13238-010-0010-5

http://link.springer.com/content/pdf/10.1007/s13238-010-0010-5

21 November 2024

1 reference

DOI

https://api.crossref.org/works/10.1007/S13238-010-0010-5

21 November 2024

1 reference

4 August 2017

volume

1

1 reference

4 August 2017

issue

2

1 reference

4 August 2017

page(s)

117-123

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Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

4 August 2017

cites work

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PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

8 July 2018

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8 July 2018

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PALB2 is an integral component of the BRCA complex required for homologous recombination repair

8 July 2018

1 reference

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PALB2 links BRCA1 and BRCA2 in the DNA-damage response

8 July 2018

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NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

8 July 2018

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MERIT40 facilitates BRCA1 localization and DNA damage repair

8 July 2018

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MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

8 July 2018

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Regulatory ubiquitylation in response to DNA double-strand breaks

8 July 2018

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Histone ubiquitination associates with BRCA1-dependent DNA damage response

8 July 2018

1 reference

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Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to preclinical utility

8 July 2018

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The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

8 July 2018

1 reference

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

8 July 2018

1 reference

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

8 July 2018

1 reference

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

8 July 2018

1 reference

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CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

8 July 2018

1 reference

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CCDC98 targets BRCA1 to DNA damage sites

8 July 2018

1 reference

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Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

8 July 2018

1 reference

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Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

8 July 2018

1 reference

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A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

8 July 2018

1 reference

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A mouse model of basal-like breast carcinoma with metaplastic elements

8 July 2018

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Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

8 July 2018

1 reference

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Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

8 July 2018

1 reference

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

The role of BRCA1 in non-homologous end-joining

8 July 2018

1 reference

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PARP inhibitors for cancer therapy.

8 July 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

8 July 2018

1 reference

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

8 July 2018

1 reference

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

8 July 2018

1 reference

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DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

8 July 2018

1 reference

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Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1.

8 July 2018

1 reference

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BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

The BRCT Domain Is a Phospho-Protein Binding Domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

PARP-1, a determinant of cell survival in response to DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Molecular views of recombination proteins and their control

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Interactions of the Nijmegen breakage syndrome protein with ATM and BRCA1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Cell-cycle responses to DNA damage in G2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Structural consequences of a cancer-causing BRCA1-BRCT missense mutation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Tumor formation in Brca1 conditional mutant mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Cancer susceptibility and the functions of BRCA1 and BRCA2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

ATM phosphorylates histone H2AX in response to DNA double-strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Direct DNA binding by Brca1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

DNA mismatch repair and genetic instability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Independence of R/M/N focus formation and the presence of intact BRCA1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

The G2-phase DNA-damage checkpoint

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Genetic analysis of BRCA1 function in a defined tumor cell line

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Brca1 controls homology-directed DNA repair

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

8 July 2018

DNA breakage and repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Breast cancer susceptibility genes. BRCA1 and BRCA2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

S phase damage sensing checkpoints in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Association of BRCA1 with Rad51 in mitotic and meiotic cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Evidence for a transcriptional activation function of BRCA1 C-terminal region

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Cell cycle control and cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

G1 control in mammalian cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Radioresistant DNA synthesis: an intrinsic feature of ataxia telangiectasia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Checkpoints: controls that ensure the order of cell cycle events

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Linkage of early-onset familial breast cancer to chromosome 17q21

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.

8 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

BRCA1 mutations in primary breast and ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

Brca1 required for T cell lineage development but not TCR loci rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

Primary fibroblasts from BRCA1 heterozygotes display an abnormal G1/S cell cycle checkpoint following UVA irradiation but show normal levels of micronuclei following oxidative stress or mitomycin C treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13238-010-0010-5

Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3078634

Epidemiology, prevention, and early detection of breast cancer

26 October 2018

1 reference

12 December 2020

BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks

1 reference

12 December 2020

Postgastrectomy small intestine adhesions

1 reference

12 December 2020

Location of BRCA1 in human breast and ovarian cancer cells

1 reference

12 December 2020

Identifiers

DOI

1 reference

Dimensions Publication ID

4 August 2017

0 references

1 reference

4 August 2017

1 reference