Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin. (Q34802673)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24766300%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

title

Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin (English)

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16 March 2020

1

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16 March 2020

Amit Kumar

3

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16 March 2020

Sama F Sleiman

4

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16 March 2020

Brett Langley

10

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16 March 2020

Susan Bane

12

1 reference

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16 March 2020

Irina Gazaryan

14

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16 March 2020

Anatoly Starkov

15

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16 March 2020

Julie K Andersen

16

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16 March 2020

author name string

Saravanan S Karuppagounder

2

1 reference

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16 March 2020

Manuela Basso

5

1 reference

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16 March 2020

Thong Ma

6

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16 March 2020

Ambreena Siddiq

7

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16 March 2020

Shankar J Chinta

8

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16 March 2020

Camille Brochier

9

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16 March 2020

Renee Haskew-Layton

11

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Gregory J Riggins

13

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16 March 2020

Rajiv R Ratan

17

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16 March 2020

publication date

1 January 2015

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Antioxidants & Redox Signaling

16 March 2020

published in

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16 March 2020

volume

22

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issue

2

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16 March 2020

page(s)

121-134

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FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption

16 March 2020

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

8 July 2018

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8 July 2018

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Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury

8 July 2018

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8 July 2018

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

8 July 2018

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8 July 2018

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8 July 2018

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Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection

8 July 2018

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Harnessing hypoxic adaptation to prevent, treat, and repair stroke.

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

8 July 2018

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8 July 2018

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Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line.

8 July 2018

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Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

8 July 2018

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Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases

8 July 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

8 July 2018

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Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia

8 July 2018

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Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]

8 July 2018

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Beta-tubulin genes from the parasitic nematode Haemonchus contortus modulate drug resistance in Caenorhabditis elegans

8 July 2018

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Purification and characterization of hypoxia-inducible factor 1

8 July 2018

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Mode of action of the anthelminthic thiabendazole in Haemonchus contortus

8 July 2018

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The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles

8 July 2018

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Specific interaction of benzimidazole anthelmintics with tubulin: high-affinity binding and benzimidazole resistance in Haemonchus contortus.

8 July 2018

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Rapid isolation of metabolically active mitochondria from rat brain and subregions using Percoll density gradient centrifugation

8 July 2018

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A possible biochemical mode of action for benzimidazole anthelmintics.

8 July 2018

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Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents

8 July 2018

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Interaction of anthelmintic benzimidazoles and benzimidazole derivatives with bovine brain tubulin

8 July 2018

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Comparison of peripheral and central effects of single and repeated oral dose administrations of bilastine, a new H1 antihistamine: a dose-range study in healthy volunteers with hydroxyzine and placebo as control treatments

8 July 2018

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Blood pressure lowering after experimental cerebral ischemia provides neurovascular protection

26 October 2018

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Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.

26 October 2018

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Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke.

26 October 2018

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Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

26 October 2018

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Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin

26 October 2018

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The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

26 October 2018

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Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein

26 October 2018

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Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system

26 October 2018

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Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione.

26 October 2018

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Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24766300

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The binding of isocolchicine to tubulin. Mechanisms of ligand association with tubulin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24766300

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24766300

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1089/ARS.2013.5595

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24766300%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24766300%20AND%20SRC:MED&resulttype=core&format=json

16 March 2020

PubMed publication ID

24766300

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24766300%20AND%20SRC:MED&resulttype=core&format=json