A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease (Q34795840)

4 August 2017

title

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease (English)

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4 August 2017

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2

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19

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22

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Nayana Lahiri

6

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Mahmoud A. Pouladi

Mahmoud A Pouladi

14

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Denis Soulet

Denis Soulet

10

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Michael R. Hayden

Michael R Hayden

15

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Sam Brundin

18

Patrik Brundin

1 reference

4 August 2017

20

Blair R Leavitt

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ORCID Public Data File 2021

4 August 2017

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author name string

Maria Björkqvist

1

1 reference

4 August 2017

Jenny Thiele

3

1 reference

4 August 2017

Aurelio Silvestroni

4

1 reference

4 August 2017

Ralph Andre

5

1 reference

4 August 2017

Elsa Raibon

7

1 reference

4 August 2017

Richard V Lee

8

1 reference

4 August 2017

Caroline L Benn

9

1 reference

4 August 2017

Anna Magnusson

11

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4 August 2017

Ben Woodman

12

1 reference

4 August 2017

Christian Landles

13

1 reference

4 August 2017

Azadeh Khalili-Shirazi

16

1 reference

4 August 2017

Mark W Lowdell

17

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4 August 2017

Thomas Möller

21

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4 August 2017

language of work or name

English

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publication date

14 July 2008

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Journal of Experimental Medicine

4 August 2017

published in

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4 August 2017

volume

205

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4 August 2017

issue

8

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4 August 2017

page(s)

1869-1877

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Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

4 August 2017

cites work

1 reference

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Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

8 July 2018

1 reference

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Adipokines and the blood-brain barrier

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Intravenous immunoglobulins in refractory childhood-onset epilepsy: effects on seizure frequency, EEG activity, and cerebrospinal fluid cytokine profile

8 July 2018

1 reference

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Progressive alterations in the hypothalamic-pituitary-adrenal axis in the R6/2 transgenic mouse model of Huntington's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Regional and cellular gene expression changes in human Huntington's disease brain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

8 July 2018

1 reference

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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

8 July 2018

1 reference

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Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

8 July 2018

1 reference

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

8 July 2018

1 reference

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Expression and biologic characterization of the murine chemokine KC.

8 July 2018

1 reference

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Multiple comparisons and related issues in the interpretation of epidemiologic data

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

The meaning and use of the area under a receiver operating characteristic (ROC) curve

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Testicular degeneration in Huntington disease.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Microglial activation in presymptomatic Huntington's disease gene carriers

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Predict-HD and the future of therapeutic trials

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Weight changes in Huntington's disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Cerebrospinal fluid IL-6, HSP72, and TNF-alpha in exercising humans

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Combination of serum markers related to several mechanisms in Alzheimer's disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Pharmacological analysis of signal transduction pathways required for mycobacterium tuberculosis-induced IL-8 and MCP-1 production in human peripheral monocytes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Early and progressive accumulation of reactive microglia in the Huntington disease brain

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Formation of polyglutamine inclusions in non-CNS tissue

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Unified Huntington's disease rating scale: Reliability and consistency

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2525598

Increased cytotoxic potential of microglia from ALS-transgenic mice

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18625748

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Complement expression in human brain. Biosynthesis of terminal pathway components and regulators in human glial cells and cell lines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18625748

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20080178

1 reference

4 August 2017

1 reference

4 August 2017

1 reference