Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia (Q34747208)

4 August 2017

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title

Finding the next Gleevec: FLT3 targeted kinase inhibitor therapy for acute myeloid leukemia (English)

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4 August 2017

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Charles L Sawyers

1

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4 August 2017

publication date

1 June 2002

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4 August 2017

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4 August 2017

volume

1

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4 August 2017

issue

5

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4 August 2017

page(s)

413-415

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High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

4 August 2017

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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

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7 January 2021

The conformational plasticity of protein kinases

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7 January 2021

Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

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Comprehensive genotypic analysis of leukemia: clinical and therapeutic implications

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FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

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7 January 2021

CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML).

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A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

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A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

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7 January 2021

Chronic myeloid leukemia

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7 January 2021

Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.

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7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

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7 January 2021

Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study

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7 January 2021

BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study

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7 January 2021

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412.

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

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7 January 2021

10.1016/S1535-6108(02)00080-6

Identifiers

DOI

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4 August 2017

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