Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate (Q34719423)

4 August 2017

title

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate (English)

1 reference

4 August 2017

Xiaoqing Gan

1

1 reference

4 August 2017

Jiyong Wang

series ordinal

2

1 reference

4 August 2017

Bing Su

series ordinal

3

1 reference

4 August 2017

Dianqing Wu

series ordinal

4

1 reference

4 August 2017

language of work or name

English

0 references

publication date

10 February 2011

1 reference

Journal of Biological Chemistry

4 August 2017

published in

1 reference

4 August 2017

volume

286

1 reference

4 August 2017

issue

13

1 reference

4 August 2017

page(s)

10998-11002

1 reference

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action

4 August 2017

cites work

1 reference

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mTOR and the control of whole body metabolism

7 July 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

7 July 2018

1 reference

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

7 July 2018

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

7 July 2018

1 reference

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TOR regulation of AGC kinases in yeast and mammals

7 July 2018

1 reference

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PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

mTOR, translation initiation and cancer

7 July 2018

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

7 July 2018

1 reference

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TOR signaling in growth and metabolism

7 July 2018

1 reference

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TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium

7 July 2018

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

7 July 2018

1 reference

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

7 July 2018

1 reference

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Transformation potential of Ras isoforms correlates with activation of phosphatidylinositol 3-kinase but not ERK.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

TOR2 is required for organization of the actin cytoskeleton in yeast

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3064154

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.195016

Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.195016

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.195016

Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.195016

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21310961

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phosphatidylinositol 3-kinase functions as a Ras effector in the signaling cascade that regulates dephosphorylation of the actin-remodeling protein cofilin after costimulation of untransformed human T lymphocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21310961

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.195016

1 reference

4 August 2017

1 reference

4 August 2017

1 reference