Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness (Q34707848)

4 August 2017

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title

Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness (English)

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4 August 2017

3

Brogden RN

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4 August 2017

Heel RC

1

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4 August 2017

Morley PA

2

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4 August 2017

Carmine AA

4

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4 August 2017

Speight TM

5

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4 August 2017

Avery GS

6

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4 August 2017

publication date

1 September 1982

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4 August 2017

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4 August 2017

volume

24

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4 August 2017

issue

3

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4 August 2017

page(s)

169-206

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Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues

4 August 2017

cites work

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12 December 2020

An examination of possible interactions between zimelidine, a serotonin uptake inhibitor, and ethanol ingested conjointly in human subjects

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12 December 2020

Effects of amitriptyline and zimelidine in combination with ethanol

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12 December 2020

Rapid mood cycles after a noradrenergic but not a serotonergic antidepressant

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12 December 2020

Effect of antidepressants, lithium and electroconvulsive treatment on rat serum prolactin levels

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12 December 2020

Effect of zimelidine (H 102/09) in depressive patients

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12 December 2020

Zimelidine: A therapeutic and pharmacokinetic study in depression

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12 December 2020

Changes in the augmenter-reducer tendency and in pain measures as a result of treatment with a serotonin-reuptake inhibitor--zimelidine

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12 December 2020

Reversed-phase chromatography of zimelidine and similar dibasic amines. I. Analysis in biological material

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12 December 2020

Event recording in a clinical trial of a new medicine

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12 December 2020

Pharmacokinetics of zimelidine. Systemic availability of zimelidine and norzimelidine in human volunteers

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12 December 2020

Single dose pharmacokinetic data on zimelidine in depressed patients

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12 December 2020

Absence of platelet monamine oxidase inhibition during amitriptyline or zimelidine treatment

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12 December 2020

Pharmacokinetics of zimelidine in humans--plasma levels and urinary excretion of zimelidine and norzimelidine after intravenous and oral administration of zimelidine

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12 December 2020

Preliminary clinical test of zimelidine (H 102/09), a new 5-HT uptake inhibitor

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12 December 2020

Tricyclic Antidepressant Agents. I. Comparison of the Inhibition of the Uptake of 3H-Noradrenaline and 14C-5-Hydroxytryptamine in Slices and Crude Synaptosome Preparations of the Midbrain-Hypothalamus Region of the Rat Brain

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12 December 2020

Long-Term Antidepressant Treatment Decreases Spiroperidol-Labeled Serotonin Receptor Binding

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12 December 2020

Interaction studies between three antidepressant drugs (zimelidine, imipramine and chlorimipramine) and noradrenaline in healthy volunteers and some pharmacokinetics of the drugs studied

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12 December 2020

Changes in saliva secretion and accommodation width during short-term administration of imipramine and zimelidine in healthy volunteers

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12 December 2020

Interactions between reserpine and various compounds on the accumulation of [14C] 5-hydroxytryptamine and [3H]noradrenaline in homogenates from rat hypothalamus

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12 December 2020

5-Hydroxytryptamine depletion and avoidance acquisition in the rat. Antagonism of the long-term effects of p-chloroamphetamine with a selective inhibitor of 5-hydroxytryptamine uptake

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12 December 2020

The antidepressant efficacy of zimelidine and maprotiline

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12 December 2020

Inhibition of 5-hydroxytryptamine reuptake by amitriptyline and zimelidine and its relationship to their therapeutic action

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12 December 2020

Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin

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12 December 2020

A double blind comparison of zimelidine and amitriptyline in endogenous depression

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12 December 2020

Stereoselective inhibition of 3H-imipramine binding by antidepressant drugs and their derivatives

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12 December 2020

(Z)-dimethylamino-1-(4-bromophenyl)-1-(3-pyridyl) propene (h 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake

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12 December 2020

Metabolism of zimelidine in rat, dog and man. Identification and synthesis of the principal metabolites.

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12 December 2020

Effects of clomipramine and other inhibitors of monoamine uptake on the sexual behaviour of female rats and rhesus monkeys

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12 December 2020

Zimelidine vs maprotiline in depressed outpatients. A preliminary report

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12 December 2020

Antagonism of the acute and long-term biochemical effects of 4-chloroamphetamine on the 5-HT neurones in the rat brain by inhibitors of the 5-hydroxytryptamine uptake

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12 December 2020

The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor

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12 December 2020

Initial clinical trial based on biochemical methodology of zimelidine (a serotonin uptake inhibitor) in depressed patients

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12 December 2020

Visual evoked potentials as a predictor of reported side effects during a trial of zimelidine vs. placebo in chronic pain patients

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12 December 2020

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12 December 2020

Effects of antidepressant agents on the synthesis of brain monoamines

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12 December 2020

A double-blind controlled study of a serotonin uptake inhibitor (Zimelidine) versus placebo in chronic pain patients

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12 December 2020

Zimelidine and norzimelidine protein binding measured by equilibrium dialysis and cerebrospinal fluid

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12 December 2020

Potent and long-lasting potentiation of two 5-hydroxytryptophan-induced effects in mice by three selective 5-HT uptake inhibitors

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12 December 2020

Adverse effects of antidepressant drugs. Part 1: monoamine oxidase inhibitors and tricyclics

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12 December 2020

Potentiation of the antidepressant action of clomipramine by tryptophan

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12 December 2020

Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats: II. Possible interaction with brain norepinephrine

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12 December 2020

Efflux of 5-hydroxytryptamine from synaptosomes of rat cerebral cortex

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12 December 2020

The classification of depressions: a review of contemporary confusion

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12 December 2020

High-affinity 3H-imipramine binding in rat cerebral cortex

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12 December 2020

Safety data on zimelidine hydrochloride following an overdose.

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12 December 2020

5-Hydroxytryptamine neurons and the sleep-wakefulness cycle. Effects of methergoline and zimelidine

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12 December 2020

Cardiovascular effects of amitriptyline, mianserin and zimelidine in depressed patients

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12 December 2020

Generalized lipidosis in rats following treatment with amiodarone and zimelidine

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12 December 2020

Cardiovascular effects of amitriptyline, mianserin, zimelidine and nomifensine in depressed patients

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12 December 2020

Maprotiline, nomifensine, mianserin, zimelidine: a review of antidepressant efficacy in in-patients

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12 December 2020

Zimelidine-induced lipidosis in rats

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12 December 2020

Action of mianserin and zimelidine on the norepinephrine receptor coupled adenylate cyclase system in brain: Subsensitivity without reduction in β-adrenergic receptor binding

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12 December 2020

Prolongation of the ejaculation latency in the male rat by thioridazine and chlorimipramine

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12 December 2020

Blood platelets as a model for monoamine-containing neurones

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12 December 2020

The treatment of phobic anxiety by zimelidine.

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12 December 2020

Interaction studies between three antidepressant drugs (chlorimipramine, imipramine and zimelidine) and noradrenaline, tyramine and vagal stimulation on the heart rate and blood pressure in dogs

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12 December 2020

Cardiovascular effects of zimelidine and other antidepressant in conscious rats

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12 December 2020

Zimelidine and amitriptyline in the treatment of depressive illness in general practice

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12 December 2020

Influence of depression and antidepressants on weight

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12 December 2020

Pre- and postsynaptic effects of zimelidine and norzimelidine on the serotoninergic system: single cell studies in the rat

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12 December 2020

Inhibition of 5-hydroxytryptamine uptake in human platelets by antidepressant agents in vivo

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12 December 2020

Plasma levels of zimelidine and norzimelidine in endogenous depression

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12 December 2020

Cardiovascular, sedative and anticholinergic effects of amitriptyline and zimelidine in young and elderly volunteers

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12 December 2020

Zimelidine - a serotonin uptake blocker in the treatment of phobic anxiety

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12 December 2020

Long-term treatment with zimelidine leads to a reduction in 5-hydroxytryptamine neurotransmission within the central nervous system of the mouse and rat

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12 December 2020

A pilot study of the effect of the 5-HT-uptake inhibitor, zimelidine, on phobic anxiety.

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12 December 2020

Plasma Level Monitoring of Tricyclic Antidepressant Therapy

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12 December 2020

Zimelidine: comparison of different dosage regimes in general practice

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12 December 2020

Biogenic amine hypothesis of affective disorders

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12 December 2020

Comparative pharmacokinetics of zimelidine and desipramine in man following acute and chronic administration

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12 December 2020

Treatment of phobic neurosis with clomipramine: a controlled clinical trial

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12 December 2020

Zimelidine and clomipramine: Different influence on fenfluramine but not p-chloroamphetamine-induced pharmacological effects

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12 December 2020

Serotonin and noradrenaline uptake inhibitors in the treatment of depression - relationship to 5-HIAA in spinal fluid

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12 December 2020

The action of antidepressant drugs on 5-hydroxy-tryptamine uptake by platelets--relationship to therapeutic effect

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12 December 2020

Acute effects of zimelidine and alaproclate, two inhibitors of serotonin uptake, on neuroendocrine function

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12 December 2020

A double?blind study of zimelidine, a serotonin uptake inhibitor, and desipramine, a noradrenaline uptake inhibitor, in endogenous depression

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12 December 2020

Comparison of peripheral anticholinergic effects of antidepressants: dry mouth

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12 December 2020

Biochemical effects of zimelidine in man

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12 December 2020

Evidence for stabilization of cortical 5HT neurotransmission by chronic treatment with antidepressant drugs: induction of a high and a low affinity component in 3H-5HT binding sites

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12 December 2020

5-HT reuptake inhibitors plus tryptophan in endogenous depression

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12 December 2020

Comparison of the cardiovascular effects of amitriptyline and zimelidine using thoracic impedance cardiography

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12 December 2020

Critical flicker fusion (CFF) test for sedative effect of antidepressants

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12 December 2020

Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline

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12 December 2020

Controlled cross-over study of a 5-HT uptake inhibiting and an NA uptake inhibiting antidepressant

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12 December 2020

Test-specific effects of the 5-HT reuptake inhibitors alaproclate and zimelidine on pain sensitivity and morphine analgesia

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12 December 2020

The effect of antidepressants on L-5HTP-induced changes in rat plasma corticosteroids.

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12 December 2020

Anti-aggressive effect of zimelidine in isolated mice

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12 December 2020

Comparison between zimelidine and desipramine in endogenous depression. A cross-over study

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12 December 2020

Zimelidine to geriatric patients: a pharmacokinetic and clinical study

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12 December 2020

Attenuation of pethidine-induced antinociception by zimelidine, an inhibitor of 5-hydroxytryptamine reuptake

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12 December 2020

The effects of subchronic antidepressant drug treatment on the secretion of adenohypophyseal hormones and of corticosterone in the male rat.

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12 December 2020

The effects of chronic treatment with the 5-hydroxytryptamine uptake blocker zimelidine on central 5-hydroxytryptamine mechanisms. Evidence for the induction of a low affinity binding site for 5-hydroxytryptamine.

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12 December 2020

Effects of zimelidine on serotoninergic and noradrenergic neurons after repeated administration in the rat

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12 December 2020

Commentary. Depression and antidepressant drugs

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12 December 2020

Sedative/anxiolytic effects of antidepressants in animals

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12 December 2020

Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression

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12 December 2020

The clinical assessment of depression

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12 December 2020

Crossover study of zimelidine and desipramine in depression: evidence for amine specificity [proceedings]

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12 December 2020

On the mechanism of the acute decrease of rat brain tryptophan hydroxylase activity by 4-chloroamphetamine

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12 December 2020

Effects of antidepressant drugs on different receptors in the brain

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12 December 2020

Effect of zimelidine, a new antidepressant, on appetite and body weight

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12 December 2020

Effects of zimelidine, a selective 5-HT uptake inhibitor, on serum prolactin levels in man

1 reference

12 December 2020

L-Tryptophan and 5-hydroxytryptophan in the treatment of depression

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12 December 2020

CGP 6085 A, a new, specific, inhibitor of serotonin uptake: neurochemical characterization and comparison with other serotonin uptake blockers

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12 December 2020

Binding of a specific 5-HT uptake inhibitor, [3H]norzimelidine, to rat brain homogenates.

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12 December 2020

Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs

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12 December 2020

Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats. I. Involvement of brain 5-hydroxytryptamine in the mediation of the positive reinforcing properties of ethanol

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12 December 2020

Reduction of voluntary morphine consumption following treatment with zimelidine

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12 December 2020

A clinical trial of zimelidine in depression

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12 December 2020

Specific norepinephrine and serotonin uptake inhibitors in man: a crossover study with pharmacokinetic, biochemical, neuroendocrine and behavioral parameters.

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12 December 2020

5-Hydroxytryptamine and avoidance performance in the rat. Antagonism of the acute effect of p-chloroamphetamine by zimelidine, an inhibitor of 5-hydroxytryptamine uptake

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12 December 2020

Antidepressant drugs and ethanol: Behavioral and pharmacokinetic interactions in mice

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12 December 2020

Changes in endorphins and 5-hydroxyindoleacetic acid in cerebrospinal fluid as a result of treatment with a serotonin reuptake inhibitor (zimelidine) in chronic pain patients

1 reference

12 December 2020

Double-blind comparisons of a selective serotonin reuptake inhibitor, zimelidine, and placebo on quantified EEG parameters and psychological variables.

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12 December 2020

Some current problems related to the mode of action of antidepressant drugs

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12 December 2020

Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness

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12 December 2020

10.2165/00003495-198224030-00001

Identifiers

DOI

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Dimensions Publication ID

4 August 2017

1041854806

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