PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma (Q34703660)

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English	PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

4 August 2017

PCI-24781 (abexinostat), a novel histone deacetylase inhibitor, induces reactive oxygen species-dependent apoptosis and is synergistic with bortezomib in neuroblastoma (English)

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Europe PubMed Central

PubMed publication ID

4 August 2017

reactive oxygen species

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based on heuristic

inferred from title

Stephen Roberts

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25520806%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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Giselle Saulnier Sholler

1

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11 June 2020

Erika A Currier

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25520806%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Akshita Dutta

3

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11 June 2020

Marni A Slavik

4

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11 June 2020

Sharon A Illenye

5

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11 June 2020

Maria Cecilia F Mendonca

6

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11 June 2020

Julie Dragon

7

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11 June 2020

Jeffrey P Bond

9

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11 June 2020

publication date

1 December 2013

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4 August 2017

Journal of cancer therapeutics & research

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11 June 2020

2

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11 June 2020

21

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25520806%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

RuvBL2 is involved in histone deacetylase inhibitor PCI-24781-induced cell death in SK-N-DZ neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Notch signalling in solid tumours: a little bit of everything but not all the time

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Notch1 regulates the growth of human colon cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Outcomes for children and adolescents with cancer: challenges for the twenty-first century

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7 July 2018

PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

HDACi--targets beyond chromatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Experimental study on inhibitory effects of histone deacetylase inhibitor MS-275 and TSA on bladder cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Development of vorinostat: current applications and future perspectives for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Histone deacetylase 8 in neuroblastoma tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Bortezomib as a therapeutic candidate for neuroblastoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Radiosensitization by the histone deacetylase inhibitor PCI-24781.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Histone deacetylase inhibitors: overview and perspectives

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Histone deacetylase inhibitors: molecular mechanisms of action

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Trichostatin A induces apoptosis in lung cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Aberrant expression of histone deacetylase 6 in oral squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

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7 July 2018

Gene expression profiling in response to the histone deacetylase inhibitor BL1521 in neuroblastoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4266584

7 July 2018

Simpleaffy: a BioConductor package for Affymetrix Quality Control and data analysis

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7 July 2018

Characteristics of stem cells from human neuroblastoma cell lines and in tumors

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7 July 2018

Effects of the histone deacetylase inhibitor valproic acid on Notch signalling in human neuroblastoma cells.

1 reference

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7 July 2018

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

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7 July 2018

A phase 2 study of bortezomib in relapsed, refractory myeloma

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7 July 2018

Notch1 functions as a tumor suppressor in mouse skin

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7 July 2018

Summaries of Affymetrix GeneChip probe level data

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7 July 2018

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

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7 July 2018

Histone deacetylase inhibitors: a new class of potential therapeutic agents for cancer treatment.

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7 July 2018

The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

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7 July 2018

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7 July 2018

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7 July 2018

Recent advances in neuroblastoma

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26 October 2018

Effects of bortezomib on human neuroblastoma cells in vitro and in a metastatic xenograft model.

1 reference

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26 October 2018

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

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26 October 2018

The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib

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26 October 2018

Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells

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26 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25520806

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25520806

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.7243/2049-7962-2-21

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25520806%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25520806%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25520806%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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