Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. (Q34695073)

4 August 2017

title

Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. (English)

1 reference

4 August 2017

main subject

Entamoeba histolytica

1 reference

Martin E Lidell

1

1 reference

4 August 2017

Darcy M Moncada

series ordinal

2

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4 August 2017

Kris Chadee

series ordinal

3

1 reference

4 August 2017

Gunnar C Hansson

series ordinal

4

1 reference

4 August 2017

language of work or name

English

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publication date

5 June 2006

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4 August 2017

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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4 August 2017

volume

103

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4 August 2017

issue

24

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4 August 2017

page(s)

9298-9303

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Antisense inhibition of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation

4 August 2017

cites work

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7 July 2018

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The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation

7 July 2018

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7 July 2018

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The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells.

7 July 2018

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An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

7 July 2018

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Entamoeba histolytica cysteine proteinases disrupt the polymeric structure of colonic mucin and alter its protective function

7 July 2018

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The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Antisense inhibition of expression of cysteine proteinases affects Entamoeba histolytica-induced formation of liver abscess in hamsters.

7 July 2018

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O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds.

7 July 2018

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Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus

7 July 2018

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Antisense inhibition of expression of cysteine proteinases does not affect Entamoeba histolytica cytopathic or haemolytic activity but inhibits phagocytosis

7 July 2018

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Entamoeba histolytica stimulates interleukin 8 from human colonic epithelial cells without parasite-enterocyte contact

7 July 2018

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Interaction of LS174T human colon cancer cell mucins with Entamoeba histolytica: an in vitro model for colonic disease

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Role of adherence in cytopathogenic mechanisms of Entamoeba histolytica. Study with mammalian tissue culture cells and human erythrocytes

7 July 2018

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Rat and human colonic mucins bind to and inhibit adherence lectin of Entamoeba histolytica

7 July 2018

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7 July 2018

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7 July 2018

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The fast release of mucin secretion from human colonic cells induced by Entamoeba histolytica is dependent on contact and protein kinase C activation

7 July 2018

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7 July 2018

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Glycosidase activity in the excretory-secretory products of the liver fluke, Fasciola hepatica

7 July 2018

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Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0600623103

Homology modeling of Entamoeba histolytica cysteine proteinases reveals the basis for cathepsin L-like structure with cathepsin B-like specificity

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0600623103

Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins.

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0600623103

Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.

21 January 2018

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The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo

26 October 2018

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12 December 2020

Purification and characterization of the mucinase of Vibrio cholerae

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12 December 2020

Action of the major protease from Entamoeba histolytica on proteins of the extracellular matrix

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12 December 2020

Glycosidases in mucin-dwelling protozoans

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12 December 2020

Studies on the “Insoluble” Glycoprotein Complex from Human Colon

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0600623103

1 reference

4 August 2017

0 references

1 reference

4 August 2017

1 reference