The role of Th1/Th2 polarization in mucosal immunity (Q34664905)

3 August 2017

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title

The role of Th1/Th2 polarization in mucosal immunity (English)

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3 August 2017

1

Markus F Neurath

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3 August 2017

3

Laurie H Glimcher

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3 August 2017

Susetta Finotto

2

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3 August 2017

language of work or name

English

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publication date

1 June 2002

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3 August 2017

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3 August 2017

volume

8

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3 August 2017

issue

6

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3 August 2017

page(s)

567-573

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Experimental models of inflammatory bowel disease

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Airway remodeling in asthma

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Regulatory T cells in the control of immune pathology.

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Development of chronic colitis is dependent on the cytokine MIF

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

https://api.crossref.org/works/10.1038%2FNM0602-567

1 reference

7 January 2021

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Asthma genetics: not for the TIMid?

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Pulmonary T cells and eosinophils: coconspirators or independent triggers of allergic respiratory pathology?

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

The expanding universe of T-cell subsets: Th1, Th2 and more.

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Dendritic cell regulation of TH1-TH2 development

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

https://api.crossref.org/works/10.1038%2FNM0602-567

1 reference

7 January 2021

IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

The role of IL-18 in innate immunity

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Immunologic basis of antigen-induced airway hyperresponsiveness

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Modulating the immune response with dendritic cells and their growth factors

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Transcriptional regulation of Th1/Th2 polarization

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Transcription factors of the NFAT family: regulation and function

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Stability and commitment in T helper cell development

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Antibodies to interleukin 12 abrogate established experimental colitis in mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

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https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

A novel transcription factor, T-bet, directs Th1 lineage commitment

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Role of T-bet in commitment of TH1 cells before IL-12-dependent selection

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

NFATc2 and NFATc3 regulate T(H)2 differentiation and modulate TCR-responsiveness of naïve T(H)cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

ROG, repressor of GATA, regulates the expression of cytokine genes

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Essential role of T lymphocytes in the development of allergen-driven airway hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

The epidemic of allergy and asthma

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Abrogation of bronchial eosinophilic inflammation and airway hyperreactivity in signal transducers and activators of transcription (STAT)6-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Cytokine-directed therapies for asthma

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group.

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

Efficacy of soluble IL-4 receptor for the treatment of adults with asthma

1 reference

https://api.crossref.org/works/10.1038%2FNM0602-567

7 January 2021

https://api.crossref.org/works/10.1038%2FNM0602-567

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM0602-567

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3 August 2017

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