RNA interference: from basic research to therapeutic applications (Q34657942)

3 August 2017

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title

RNA interference: from basic research to therapeutic applications (English)

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3 August 2017

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Jens Kurreck

1

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language of work or name

English

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publication date

1 January 2009

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Angewandte Chemie International Edition

3 August 2017

published in

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volume

48

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3 August 2017

issue

8

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3 August 2017

page(s)

1378-1398

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Human immunodeficiency virus type 1 escape from RNA interference

3 August 2017

cites work

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12 December 2020

Enhanced gene silencing of HIV-1 specific siRNA using microRNA designed hairpins

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12 December 2020

Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions

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12 December 2020

Exploring the sounds of silence: RNAi-mediated gene silencing for target identification and validation

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12 December 2020

Antisense that comes naturally

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12 December 2020

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

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12 December 2020

RNA interference is mediated by 21- and 22-nucleotide RNAs

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12 December 2020

Universal and mutation-resistant anti-enteroviral activity: potency of small interfering RNA complementary to the conserved cis-acting replication element within the enterovirus coding region

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12 December 2020

Gutless adenovirus: last-generation adenovirus for gene therapy

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12 December 2020

siRNA efficiency: structure or sequence-that is the question

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12 December 2020

Antitumor activity of an oncolytic adenovirus-delivered oncogene small interfering RNA.

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12 December 2020

Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells

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12 December 2020

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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12 December 2020

Role for a bidentate ribonuclease in the initiation step of RNA interference

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12 December 2020

Reversible gene knockdown in mice using a tight, inducible shRNA expression system

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12 December 2020

RNA interference in mammalian cells by chemically-modified RNA.

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12 December 2020

Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions

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12 December 2020

Experimental validation of the importance of seed complement frequency to siRNA specificity

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12 December 2020

Single copy shRNA configuration for ubiquitous gene knockdown in mice

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12 December 2020

RNAi and gene therapy: a mutual attraction

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12 December 2020

Aptamer mediated siRNA delivery

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12 December 2020

Target accessibility dictates the potency of human RISC

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12 December 2020

Sfold web server for statistical folding and rational design of nucleic acids

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12 December 2020

RNA Interference with chemically modified siRNA.

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12 December 2020

Rational siRNA design for RNA interference

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12 December 2020

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

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12 December 2020

RNA interference in pain research

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12 December 2020

Tissue-specific and cell type-specific RNA interference in vivo

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12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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12 December 2020

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

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12 December 2020

A protein sensor for siRNA asymmetry

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12 December 2020

Lentiviral-mediated RNA interference

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12 December 2020

Gene therapy clinical trials worldwide to 2007--an update.

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12 December 2020

Crystal structure of Argonaute and its implications for RISC slicer activity

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12 December 2020

Progress in antisense technology.

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12 December 2020

From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy

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12 December 2020

A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

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12 December 2020

Lentiviral vector design for multiple shRNA expression and durable HIV-1 inhibition

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12 December 2020

Conditional gene knock-down by CRE-dependent short interfering RNAs

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12 December 2020

Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

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12 December 2020

The 2-5A system: modulation of viral and cellular processes through acceleration of RNA degradation

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12 December 2020

siRNAs can function as miRNAs

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12 December 2020

Coxsackievirus B3 and adenovirus infections of cardiac cells are efficiently inhibited by vector-mediated RNA interference targeting their common receptor

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12 December 2020

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.

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12 December 2020

miRNAs in the biology of cancers and viral infections

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12 December 2020

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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12 December 2020

Developing an effective RNA interference strategy against a plus-strand RNA virus: silencing of coxsackievirus B3 and its cognate coxsackievirus-adenovirus receptor

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12 December 2020

Tumor inhibition by genomically integrated inducible RNAi-cassettes

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12 December 2020

Expression profiling reveals off-target gene regulation by RNAi

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12 December 2020

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo

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12 December 2020

Simultaneous targeting of HCV replication and viral binding with a single lentiviral vector containing multiple RNA interference expression cassettes.

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12 December 2020

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

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12 December 2020

Improved silencing properties using small internally segmented interfering RNAs

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12 December 2020

Poliovirus escape from RNA interference: short interfering RNA-target recognition and implications for therapeutic approaches

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12 December 2020

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

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12 December 2020

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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12 December 2020

Interactions between double-stranded RNA regulators and the protein kinase DAI

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12 December 2020

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

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12 December 2020

Development of therapeutic siRNAs for pachyonychia congenita

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12 December 2020

Cancer proliferation gene discovery through functional genomics.

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12 December 2020

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12 December 2020

Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions

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12 December 2020

RNA and microRNAs in fragile X mental retardation

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12 December 2020

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

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12 December 2020

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

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12 December 2020

Stable suppression of tumorigenicity by virus-mediated RNA interference

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12 December 2020

A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats

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12 December 2020

Mammalian RNAi for the masses

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12 December 2020

Local RNA target structure influences siRNA efficacy: a systematic global analysis

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12 December 2020

Adenovirus-mediated RNA interference against foot-and-mouth disease virus infection both in vitro and in vivo

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12 December 2020

Germline transmission of RNAi in mice

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12 December 2020

Effect of target secondary structure on RNAi efficiency

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12 December 2020

Phospholamban ablation by RNA interference increases Ca2+ uptake into rat cardiac myocyte sarcoplasmic reticulum

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12 December 2020

RNA interference in adult mice.

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12 December 2020

Inhibition of influenza virus production in virus-infected mice by RNA interference

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12 December 2020

Identification of host proteins required for HIV infection through a functional genomic screen

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12 December 2020

Enzymatically prepared RNAi libraries

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12 December 2020

Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.

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12 December 2020

RNA targeting with peptide conjugates of oligonucleotides, siRNA and PNA.

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12 December 2020

Cellular uptake and localization of a Cy3-labeled siRNA specific for the serine/threonine kinase Pim-1.

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12 December 2020

Induction of an interferon response by RNAi vectors in mammalian cells

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12 December 2020

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

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12 December 2020

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

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12 December 2020

Specificity of short interfering RNA determined through gene expression signatures

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12 December 2020

Return to the RNAi world: rethinking gene expression and evolution (Nobel Lecture).

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12 December 2020

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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12 December 2020

Phosphorothioate-stimulated uptake of short interfering RNA by human cells

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12 December 2020

Inhibition of respiratory viruses by nasally administered siRNA.

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12 December 2020

Synthetic shRNAs as potent RNAi triggers

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12 December 2020

Down-regulation of expression of rat pyruvate dehydrogenase E1alpha gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery

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12 December 2020

RNAi-mediated gene silencing in non-human primates.

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12 December 2020

Off-target effects by siRNA can induce toxic phenotype

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12 December 2020

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis.

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12 December 2020

Design of a genome-wide siRNA library using an artificial neural network

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12 December 2020

Chemical modification: the key to clinical application of RNA interference?

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12 December 2020

The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race

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12 December 2020

Locked nucleic acid: high-affinity targeting of complementary RNA for RNomics.

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12 December 2020

Strategies for silencing human disease using RNA interference

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12 December 2020

In vivo imaging of siRNA delivery and silencing in tumors

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12 December 2020

Anti-coxsackieviral efficacy of RNA interference is highly dependent on genomic target selection and emergence of escape mutants

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12 December 2020

Focusing on RISC assembly in mammalian cells.

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12 December 2020

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

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12 December 2020

Complete knockdown of CCR5 by lentiviral vector-expressed siRNAs and protection of transgenic macrophages against HIV-1 infection

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12 December 2020

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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12 December 2020

RNA learns from antisense

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12 December 2020

Prospects of RNA interference therapy for cancer

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12 December 2020

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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12 December 2020

siRNA Delivery into Human T Cells and Primary Cells with Carbon-Nanotube Transporters

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12 December 2020

The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides

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12 December 2020

Gene silencing by double-stranded RNA (Nobel Lecture).

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12 December 2020

Small interfering RNA and gene silencing in transgenic mice and rats

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12 December 2020

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

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12 December 2020

Rapid and highly efficient transduction by double-stranded adeno-associated virus vectors in vitro and in vivo

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12 December 2020

The business of RNAi therapeutics

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12 December 2020

A systematic analysis of the effect of target RNA structure on RNA interference

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12 December 2020

Functional siRNAs and miRNAs Exhibit Strand Bias

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12 December 2020

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).

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12 December 2020

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

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12 December 2020

Suppression of human brain tumor with interference RNA specific for tenascin-C.

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12 December 2020

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

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12 December 2020

Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency.

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12 December 2020

siRNA and isRNA: two edges of one sword

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12 December 2020

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells

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12 December 2020

Locked nucleic acid oligonucleotides: the next generation of antisense agents?

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12 December 2020

RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy

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12 December 2020

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

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12 December 2020

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

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12 December 2020

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

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12 December 2020

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

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12 December 2020

Strand-specific silencing of a picornavirus by RNA interference: evidence for the superiority of plus-strand specific siRNAs

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12 December 2020

RNA interference against viruses: strike and counterstrike

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12 December 2020

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy

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12 December 2020

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

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12 December 2020

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12 December 2020

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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12 December 2020

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

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12 December 2020

Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference

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12 December 2020

A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA.

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12 December 2020

Suppression of prion protein in livestock by RNA interference.

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12 December 2020

Ribozyme- and deoxyribozyme-strategies for medical applications

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12 December 2020

Transvascular delivery of small interfering RNA to the central nervous system.

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12 December 2020

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

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12 December 2020

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

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12 December 2020

Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

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12 December 2020

Maintaining inhibition: siRNA double expression vectors against coxsackieviral RNAs

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12 December 2020

Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice

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12 December 2020

Argonaute2 is the catalytic engine of mammalian RNAi

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12 December 2020

Asymmetry in the assembly of the RNAi enzyme complex

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12 December 2020

Activation of the interferon system by short-interfering RNAs

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12 December 2020

Nonviral delivery of synthetic siRNAs in vivo

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12 December 2020

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

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12 December 2020

Phenotypic silencing of cytoplasmic genes using sequence-specific double-stranded short interfering RNA and its application in the reverse genetics of wild type negative-strand RNA viruses

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12 December 2020

In vitro reconstitution of the human RISC-loading complex

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12 December 2020

Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban

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12 December 2020

Silencing of mammalian genes by tetracycline-inducible shRNA expression

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12 December 2020

LNA-mediated microRNA silencing in non-human primates

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12 December 2020

Transcription and RNAi in heterochromatic gene silencing

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12 December 2020

A system for stable expression of short interfering RNAs in mammalian cells

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12 December 2020

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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12 December 2020

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

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12 December 2020

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

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12 December 2020

Insights into effective RNAi gained from large-scale siRNA validation screening

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12 December 2020

Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor

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12 December 2020

siRNA function in RNAi: a chemical modification analysis

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12 December 2020

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

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12 December 2020

Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo

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12 December 2020

Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155.

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12 December 2020

The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs

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12 December 2020

Local gene knockdown in the brain using viral-mediated RNA interference.

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12 December 2020

Trends in biotech literature 2006.

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12 December 2020

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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12 December 2020

Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).

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12 December 2020

The interplay between virus infection and the cellular RNA interference machinery

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12 December 2020

RNA interference and chemically modified small interfering RNAs

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12 December 2020

Virus treatment questioned after gene therapy death

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12 December 2020

Identifiers

DOI

10.1002/ANIE.200802092

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3 August 2017

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