Filling out the Hippo pathway (Q34648282)

3 August 2017

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title

Filling out the Hippo pathway (English)

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3 August 2017

2

Bruce A Edgar

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3 August 2017

Leslie J Saucedo

1

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3 August 2017

publication date

1 August 2007

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Nature Reviews Molecular Cell Biology

3 August 2017

published in

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3 August 2017

volume

8

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3 August 2017

issue

8

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3 August 2017

page(s)

613-621

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Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.

3 August 2017

cites work

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Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo

21 January 2018

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Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma

21 January 2018

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Drosophila in cancer research. An expanding role.

21 January 2018

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Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

31 March 2020

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Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

31 March 2020

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

31 March 2020

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From cell structure to transcription: Hippo forges a new path

31 March 2020

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Hippo signaling in organ size control

31 March 2020

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The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

31 March 2020

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The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

31 March 2020

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The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

31 March 2020

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Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

31 March 2020

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The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

31 March 2020

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salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

31 March 2020

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Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

31 March 2020

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hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

31 March 2020

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Control of cell proliferation and apoptosis by mob as tumor suppressor, mats

31 March 2020

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Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila

31 March 2020

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The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

31 March 2020

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The human tumour suppressor LATS1 is activated by human MOB1 at the membrane

31 March 2020

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Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation

31 March 2020

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The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

31 March 2020

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The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

31 March 2020

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Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription

31 March 2020

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Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

31 March 2020

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WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

31 March 2020

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Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling

31 March 2020

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Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains

31 March 2020

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A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

31 March 2020

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The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.

31 March 2020

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TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

31 March 2020

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Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis

31 March 2020

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Physical interaction with Yes-associated protein enhances p73 transcriptional activity

31 March 2020

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ERM proteins and merlin: integrators at the cell cortex

31 March 2020

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The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

31 March 2020

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The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling

31 March 2020

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Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane

31 March 2020

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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

31 March 2020

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NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

31 March 2020

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Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity

31 March 2020

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Coordination of growth and cell division in the Drosophila wing

31 March 2020

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A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila.

31 March 2020

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Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.

31 March 2020

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LATS1 tumor suppressor regulates G2/M transition and apoptosis

31 March 2020

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Lats2, a putative tumor suppressor, inhibits G1/S transition

31 March 2020

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MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

31 March 2020

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Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras

31 March 2020

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RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network.

31 March 2020

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Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila

31 March 2020

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The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily

31 March 2020

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Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing

31 March 2020

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Identification of new human cadherin genes using a combination of protein motif search and gene finding methods

31 March 2020

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Fidelity in planar cell polarity signalling.

31 March 2020

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Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling.

31 March 2020

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Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila

31 March 2020

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Long-range coordination of planar polarity in Drosophila

31 March 2020

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Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

31 March 2020

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Delineation of a Fat tumor suppressor pathway

31 March 2020

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The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

31 March 2020

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The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

31 March 2020

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Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways

31 March 2020

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Protein interaction mapping: a Drosophila case study

31 March 2020

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Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila

31 March 2020

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The bantam microRNA is a target of the hippo tumor-suppressor pathway

31 March 2020

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The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila

31 March 2020

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bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

31 March 2020

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Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

31 March 2020

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The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling

31 March 2020

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The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster

31 March 2020

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Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye.

31 March 2020

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Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage

31 March 2020

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The Drosophila RASSF homolog antagonizes the hippo pathway

31 March 2020

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Minutes: Mutants of Drosophila autonomously affecting cell division rate

31 March 2020

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The minute genes in Drosophila and their molecular functions.

31 March 2020

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Drosophila myc regulates organ size by inducing cell competition

31 March 2020

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dMyc transforms cells into super-competitors

31 March 2020

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Genes affecting cell competition in Drosophila

31 March 2020

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

31 March 2020

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The Myc trilogy: lord of RNA polymerases.

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

31 March 2020

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Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas

31 March 2020

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Mutational analysis of salvador gene in human carcinomas

31 March 2020

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Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2221

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Dimensions Publication ID

3 August 2017

1012452238

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