Design and synthesis of an irreversible dopamine-sparing cocaine antagonist (Q34647899)

3 August 2017

title

Design and synthesis of an irreversible dopamine-sparing cocaine antagonist (English)

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3 August 2017

5

Bertha K Madras

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3 August 2017

Peter C Meltzer

1

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3 August 2017

Shanghao Liu

series ordinal

2

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3 August 2017

Heather Blanchette

series ordinal

3

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3 August 2017

Paul Blundell

series ordinal

4

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3 August 2017

language of work or name

English

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publication date

1 November 2002

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Bioorganic & Medicinal Chemistry

3 August 2017

published in

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3 August 2017

volume

10

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3 August 2017

issue

11

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3 August 2017

page(s)

3583-3591

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Sodium dependent [3H]cocaine binding associated with dopamine uptake sites in the rat striatum and human putamen decrease after dopaminergic denervation and in Parkinsons disease

3 August 2017

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Autoradiographic localization of cocaine binding sites by [3H]CFT ([3H]WIN 35,428) in the monkey brain

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Chemistry, design, and structure-activity relationship of cocaine antagonists

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Synthesis, ligand binding, and QSAR (CoMFA and classical) study of 3 beta-(3'-substituted phenyl)-, 3 beta-(4'-substituted phenyl)-, and 3 beta-(3',4'-disubstituted phenyl)tropane-2 beta-carboxylic acid methyl esters

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Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives

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Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding

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GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine

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Cocaine and 3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid ester and amide analogues. New high-affinity and selective compounds for the dopamine transporter

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7 January 2021

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Identifiers

DOI

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3 August 2017

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