Multiple myeloma: evolving genetic events and host interactions (Q34624999)

3 August 2017

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title

Multiple myeloma: evolving genetic events and host interactions (English)

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3 August 2017

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W Michael Kuehl

1

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3 August 2017

P Leif Bergsagel

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 March 2002

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3 August 2017

published in

Nature Reviews Cancer

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3 August 2017

volume

2

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3 August 2017

issue

3

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3 August 2017

page(s)

175-187

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Racial differences in the prevalence of monoclonal gammopathy in a community-based sample of the elderly

3 August 2017

cites work

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Monoclonal gammopathies of undetermined significance

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Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis

31 March 2020

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Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia

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Cytogenetic Abnormalities Correlate with the Plasma Cell Labeling Index and Extent of Bone Marrow Involvement in Myeloma

31 March 2020

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Chromosomal abnormalities in systemic amyloidosis

31 March 2020

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Differences in genetic changes between multiple myeloma and plasma cell leukemia demonstrated by comparative genomic hybridization

31 March 2020

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Among numerous DNA copy number changes, losses of chromosome 13 are highly recurrent in plasmacytoma

31 March 2020

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Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukemia measured using comparative genomic hybridization

31 March 2020

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Hypodiploidy is a major prognostic factor in multiple myeloma

31 March 2020

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Chromosome translocations in multiple myeloma

31 March 2020

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Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma

31 March 2020

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Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13

31 March 2020

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Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma.

31 March 2020

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

31 March 2020

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Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

31 March 2020

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Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations

31 March 2020

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A transcriptional repressor of c-myc

31 March 2020

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Experimental plasmacytomagenesis in mice

31 March 2020

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Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma

31 March 2020

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DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

31 March 2020

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Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors

31 March 2020

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Disease Progression in Patients with Multiple Myeloma is Associated with a Concurrent Alteration in the Expression of Both Oncogenes and Tumour Suppressor Genes and can be Monitored by the Oncoprotein Phenotype

31 March 2020

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Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance

31 March 2020

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Prognostic value of cytogenetics in multiple myeloma

31 March 2020

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Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy.

31 March 2020

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Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

31 March 2020

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Deletion of chromosome 13q14 detected by fluorescence in situ hybridization has prognostic impact on survival after high-dose therapy in patients with multiple myeloma

31 March 2020

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The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of undetermined significance

31 March 2020

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The retinoblastoma gene (RB-1) status in multiple myeloma: a report on 35 cases.

31 March 2020

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The retinoblastoma susceptibility gene RB-1 in multiple myeloma

31 March 2020

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Chromosome aberrations in B-cell chronic lymphocytic leukemia: reassessment based on molecular cytogenetic analysis

31 March 2020

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Genetics of chronic lymphocytic leukaemia

31 March 2020

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High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis

31 March 2020

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Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

31 March 2020

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Interleukin-6 is a growth factor for nonmalignant human plasmablasts.

31 March 2020

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Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway

31 March 2020

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

31 March 2020

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STAT3 is required for the gp130-mediated full activation of the c-myc gene

31 March 2020

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Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.

31 March 2020

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Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis.

31 March 2020

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Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

31 March 2020

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Stromal cells can contribute oncogenic signals

31 March 2020

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The microenvironment of the tumour-host interface

31 March 2020

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The role of adhesion molecules in multiple myeloma

31 March 2020

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Immune regulation in multiple myeloma: the host-tumour conflict

31 March 2020

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Stromal abnormalities in neoplastic bone marrow diseases

31 March 2020

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New insights into role of microenvironment in multiple myeloma

31 March 2020

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The tumor microenvironment as a determinant of cancer cell survival: a possible mechanism for de novo drug resistance

31 March 2020

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Interleukin-1 in multiple myeloma: producer cells and their role in the control of IL-6 production

31 March 2020

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The thin red line: angiogenesis in normal and malignant hematopoiesis

31 March 2020

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Thalidomide for previously untreated indolent or smoldering multiple myeloma

31 March 2020

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Decrease of bone marrow angiogenesis in myeloma patients achieving a remission after chemotherapy.

31 March 2020

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Serum levels of the angiogenic cytokines basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) in multiple myeloma

31 March 2020

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31 March 2020

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Biology of osteoclast activation in cancer

31 March 2020

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Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligand

31 March 2020

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Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression

31 March 2020

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A critical role for telomeres in suppressing and facilitating carcinogenesis

31 March 2020

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Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

31 March 2020

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Plasma cells: finding new light at the end of B cell development

31 March 2020

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Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival

31 March 2020

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A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Français du Myélome

31 March 2020

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31 March 2020

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Small molecule modulators of cyclin-dependent kinases for cancer therapy

31 March 2020

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Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylation

31 March 2020

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Current status of clinical trials of farnesyltransferase inhibitors.

31 March 2020

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The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells

31 March 2020

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A combination of anti-interleukin 6 murine monoclonal antibody with dexamethasone and high-dose melphalan induces high complete response rates in advanced multiple myeloma

31 March 2020

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Superoxide dismutase as a target for the selective killing of cancer cells

31 March 2020

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Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma

31 March 2020

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Antitumor activity of thalidomide in refractory multiple myeloma

31 March 2020

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Cellular origin of human B-cell lymphomas.

31 March 2020

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Mechanisms of chromosomal translocations in B cell lymphomas

31 March 2020

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

31 March 2020

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

31 March 2020

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P53 deletion is not a frequent event in multiple myeloma

31 March 2020

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p53gene mutations are rare in patients but common in patient-originating cell lines in multiple myeloma

31 March 2020

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Expression of p16INK4A and p14ARF in hematological malignancies

31 March 2020

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Role of CDK4 and p16INK4A in interleukin-6-mediated growth of multiple myeloma

31 March 2020

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Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia

31 March 2020

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p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance

31 March 2020

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Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo

31 March 2020

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Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility

31 March 2020

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A murine model of human myeloma bone disease

31 March 2020

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The 5T mouse multiple myeloma model: absence of c-myc oncogene rearrangement in early transplant generations

31 March 2020

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Cytogenetic findings in mouse multiple myeloma and Waldenström's macroglobulinemia

31 March 2020

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Organ involvement and phenotypic adhesion profile of 5T2 and 5T33 myeloma cells in the C57BL/KaLwRij mouse

31 March 2020

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Immunoglobulin VH gene sequence analysis of spontaneous murine immunoglobulin-secreting B-cell tumours with clinical features of human disease

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC746

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Dimensions Publication ID

3 August 2017

1012096528

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