Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients (Q34621219)

3 August 2017

title

Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients. (English)

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3 August 2017

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Pieter J Eichhorn

2

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Violeta Serra

Violeta Serra

8

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Aleix Prat

Aleix Prat

9

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Sabine Mai

Sabine Mai

17

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Javier Cortes

Javier Cortés

3

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author name string

Maurizio Scaltriti

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3 August 2017

Ludmila Prudkin

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Claudia Aura

5

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3 August 2017

José Jiménez

6

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3 August 2017

Sarat Chandarlapaty

7

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3 August 2017

Yasir H Ibrahim

10

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3 August 2017

Marta Guzmán

11

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3 August 2017

Magui Gili

12

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3 August 2017

Olga Rodríguez

13

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3 August 2017

Sonia Rodríguez

14

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3 August 2017

José Pérez

15

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Simon R Green

16

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3 August 2017

Neal Rosen

18

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Clifford Hudis

19

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3 August 2017

José Baselga

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language of work or name

English

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publication date

14 February 2011

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

108

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3 August 2017

issue

9

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3 August 2017

page(s)

3761-3766

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Genomic architecture characterizes tumor progression paths and fate in breast cancer patients

3 August 2017

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p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy

7 July 2018

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Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

7 July 2018

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Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.

7 July 2018

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

7 July 2018

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7 July 2018

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Ubiquinol cytochrome c reductase (UQCRFS1) gene amplification in primary breast cancer core biopsy samples

7 July 2018

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Cyclin E ablation in the mouse

7 July 2018

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The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition

7 July 2018

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Cyclin E and survival in patients with breast cancer

7 July 2018

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.

7 July 2018

1 reference

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Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab.

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1014835108

Cyclin E overexpression enhances cytokine-mediated apoptosis in MCF7 breast cancer cells

21 January 2018

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Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer

21 January 2018

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Anti-HER2 antibody trastuzumab inhibits CDK2-mediated NPAT and histone H4 expression via the PI3K pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1014835108

Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway.

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1014835108

Modulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by cell cycle inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1014835108

Cyclin E expression is a significant predictor of survival in advanced, suboptimally debulked ovarian epithelial cancers: a Gynecologic Oncology Group study

21 January 2018

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12 December 2020

Cyclin E overexpression and amplification in human tumours

1 reference

12 December 2020

Cyclin E expression in breast cancer correlates with negative steroid receptor status, HER2 expression, tumor grade and proliferation

1 reference

12 December 2020

Cyclin E confers a prognostic value in premenopausal breast cancer patients with tumours exhibiting an infiltrative growth pattern

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1014835108

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3 August 2017

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3 August 2017

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