Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism (Q34619139)

3 August 2017

title

Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism (English)

1 reference

3 August 2017

Xin Yu

1

1 reference

3 August 2017

Adam R Blanden

2

1 reference

3 August 2017

Sumana Narayanan

3

1 reference

3 August 2017

Lalithapriya Jayakumar

4

1 reference

3 August 2017

David Lubin

5

1 reference

3 August 2017

David Augeri

6

1 reference

3 August 2017

S David Kimball

7

1 reference

3 August 2017

Stewart N Loh

8

1 reference

3 August 2017

Darren R Carpizo

9

1 reference

3 August 2017

language of work or name

English

0 references

publication date

1 October 2014

1 reference

3 August 2017

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3 August 2017

volume

5

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3 August 2017

issue

19

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3 August 2017

page(s)

8879-8892

1 reference

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

3 August 2017

cites work

1 reference

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Mutational landscape and significance across 12 major cancer types

7 July 2018

1 reference

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The relationship between zinc intake and serum/plasma zinc concentration in children: a systematic review and dose-response meta-analysis

7 July 2018

1 reference

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Mutant p53: one name, many proteins

7 July 2018

1 reference

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Allele-specific p53 mutant reactivation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs.

7 July 2018

1 reference

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Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells

7 July 2018

1 reference

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The missing Zinc: p53 misfolding and cancer

7 July 2018

1 reference

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Cytosolic zinc buffering and muffling: Their role in intracellular zinc homeostasis

7 July 2018

1 reference

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Posttranslational modification of p53: cooperative integrators of function

7 July 2018

1 reference

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Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

7 July 2018

1 reference

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Structure-function-rescue: the diverse nature of common p53 cancer mutants

7 July 2018

1 reference

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Structure of the human p53 core domain in the absence of DNA

7 July 2018

1 reference

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 July 2018

1 reference

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Restoration of p53 function leads to tumour regression in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Modeling the therapeutic efficacy of p53 restoration in tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

The antioxidant function of the p53 tumor suppressor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Mdm2 promotes the rapid degradation of p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4253404

Metalloregulation of the tumor suppressor protein p53: zinc mediates the renaturation of p53 after exposure to metal chelators in vitro and in intact cells

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25294809

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Zn(2+)-dependent misfolding of the p53 DNA binding domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25294809

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.2432

0 references

PMC publication ID

4253404

1 reference

3 August 2017

1 reference