DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation (Q34612364)

3 August 2017

title

DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation (English)

1 reference

3 August 2017

Q Kong

1

1 reference

3 August 2017

N Maizels

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 May 2001

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3 August 2017

number of pages

10

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inferred from page(s)

published in

Genetics

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3 August 2017

volume

158

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3 August 2017

issue

1

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3 August 2017

page(s)

369-378

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Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes

3 August 2017

cites work

1 reference

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Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern

7 July 2018

1 reference

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The role of somatic hypermutation in the generation of deletions and duplications in human Ig V region genes and chromosomal translocations

7 July 2018

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Somatic hypermutation and the three R's: repair, replication and recombination

7 July 2018

1 reference

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Hypermutation in Ig V genes from mice deficient in the MLH1 mismatch repair protein

7 July 2018

1 reference

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Severe attenuation of the B cell immune response in Msh2-deficient mice

7 July 2018

1 reference

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TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

7 July 2018

1 reference

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Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Both DNA strands of antibody genes are hypermutation targets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

A lambda 3' enhancer drives active and untemplated somatic hypermutation of a lambda 1 transgene.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Inherent properties of somatic hypermutation as revealed by human non-productive VH6 immunoglobulin rearrangements

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

The role of DNA repair in somatic hypermutation of immunoglobulin genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Lymphocyte Development and Selection in Germinal Centers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

The germinal center: a crucible for lymphocyte selection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

The targeting of somatic hypermutation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

A lambda 1 transgene under the control of a heavy chain promoter and enhancer does not undergo somatic hypermutation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Targeting of non-Ig sequences in place of the V segment by somatic hypermutation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Mutational pattern of the nurse shark antigen receptor gene (NAR) is similar to that of mammalian Ig genes and to spontaneous mutations in evolution: the translesion synthesis model of somatic hypermutation

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Somatic hypermutation in normal and transformed human B cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Comparable impact of mutational and selective influences in shaping the expressed repertoire of peripheral IgM+/CD5− and IgM+/CD5+ B cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Mismatch repair co-opted by hypermutation.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1461619

Targeting and subsequent selection of somatic hypermutations in the human V kappa repertoire

26 October 2018

1 reference

12 December 2020

DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation

1 reference

12 December 2020

Origin of Antibody Variation

1 reference

12 December 2020

Somatic diversification of the chicken immunoglobulin light chain gene is limited to the rearranged variable gene segment

1 reference

12 December 2020

Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms

1 reference

12 December 2020

Codon bias targets mutation.

1 reference

12 December 2020

Diversification of bovine lambda-light chain genes

1 reference

12 December 2020

Somatic hypermutagenesis in immunoglobulin genes. III. Somatic mutations in the chicken light chain locus

1 reference

12 December 2020

Gene conversion contributes to Ig light chain diversity in cattle

1 reference

12 December 2020

Cis-acting sequences that affect somatic hypermutation of Ig genes

1 reference

12 December 2020

Diversification of rabbit VH genes by gene-conversion-like and hypermutation mechanisms

1 reference

12 December 2020

Localization of splenic B cells activated for switch recombination by in situ hybridization with Igamma1 switch transcript and Rad51 probes

1 reference

12 December 2020

Identifiers

PMC publication ID

1461619

1 reference

3 August 2017

1 reference