Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity (Q34512818)

2 August 2017

1 reference

title

Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity (English)

1 reference

2 August 2017

1 reference

3

Ronald S Duman

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2 August 2017

2

Eric S Wohleb

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2 August 2017

Danielle M Gerhard

1

1 reference

2 August 2017

publication date

5 February 2016

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2 August 2017

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2 August 2017

volume

21

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2 August 2017

issue

3

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2 August 2017

page(s)

454-464

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The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.

2 August 2017

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7 July 2018

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mGluR2/3 blockade produces rapid and long-lasting reversal of anhedonia caused by chronic stress exposure

7 July 2018

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Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression

7 July 2018

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Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

7 July 2018

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A randomized controlled trial of intranasal ketamine in major depressive disorder

7 July 2018

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Antidepressant treatment history as a predictor of response to scopolamine: clinical implications

7 July 2018

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Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections

7 July 2018

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REDD1 is essential for stress-induced synaptic loss and depressive behavior

7 July 2018

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Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects

7 July 2018

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Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses.

7 July 2018

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Influence of GluN2 subunit identity on NMDA receptor function.

7 July 2018

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GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects

7 July 2018

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A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression

7 July 2018

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A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression

7 July 2018

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Synaptic dysfunction in depression: potential therapeutic targets

7 July 2018

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Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

7 July 2018

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A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder

7 July 2018

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mGlu2/3 and mGlu5 receptors: potential targets for novel antidepressants

7 July 2018

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The BDNF Val66Met polymorphism impairs synaptic transmission and plasticity in the infralimbic medial prefrontal cortex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

BDNF Val66Met impairs fluoxetine-induced enhancement of adult hippocampus plasticity

7 July 2018

1 reference

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Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

7 July 2018

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Randomized, placebo-controlled trials of antidepressants for acute major depression: thirty-year meta-analytic review

7 July 2018

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¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism

7 July 2018

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mTOR activation is required for the antidepressant effects of mGluR₂/₃ blockade

7 July 2018

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Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex

7 July 2018

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Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress

7 July 2018

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Depression: The Disorder and the Burden

7 July 2018

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NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

7 July 2018

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Resilience to chronic stress is mediated by hippocampal brain-derived neurotrophic factor.

7 July 2018

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Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

7 July 2018

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Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Scopolamine Produces Larger Antidepressant and Antianxiety Effects in Women Than in Men

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Glutamate receptor ion channels: structure, regulation, and function

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Blockade of different muscarinic receptor subtypes changes the equilibrium between excitation and inhibition in rat visual cortex

7 July 2018

1 reference

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Progress in corticotropin-releasing factor-1 antagonist development

7 July 2018

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A genetic variant BDNF polymorphism alters extinction learning in both mouse and human

7 July 2018

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Replication of scopolamine's antidepressant efficacy in major depressive disorder: a randomized, placebo-controlled clinical trial

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

mTOR signaling: at the crossroads of plasticity, memory and disease

7 July 2018

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Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action.

7 July 2018

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The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats

7 July 2018

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Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide

7 July 2018

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Stress-induced dendritic remodeling in the medial prefrontal cortex: effects of circuit, hormones and rest

7 July 2018

1 reference

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Cell type-specific development of NMDA receptors in the interneurons of rat prefrontal cortex

7 July 2018

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An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

7 July 2018

1 reference

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A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus

7 July 2018

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Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

7 July 2018

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Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy

7 July 2018

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Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper

7 July 2018

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L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

7 July 2018

1 reference

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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial

7 July 2018

1 reference

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Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting.

7 July 2018

1 reference

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Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder

7 July 2018

1 reference

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Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication

7 July 2018

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MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.

7 July 2018

1 reference

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Serotonin syndrome: a brief review

7 July 2018

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Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

7 July 2018

1 reference

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The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

7 July 2018

1 reference

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Placebo response in studies of major depression: variable, substantial, and growing

7 July 2018

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Effects of nefazodone on body weight: a pooled analysis of selective serotonin reuptake inhibitor- and imipramine-controlled trials

7 July 2018

1 reference

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Genetic epidemiology of major depression: review and meta-analysis

7 July 2018

1 reference

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Cognitive, dissociative and psychotogenic effects of ketamine in recreational users on the night of drug use and 3 days later

7 July 2018

1 reference

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Antidepressant effects of ketamine in depressed patients

7 July 2018

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ECG abnormalities in tricyclic antidepressant ingestion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block.

7 July 2018

1 reference

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Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Effect of pharmacologic treatments on the sleep of depressed patients.

7 July 2018

1 reference

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Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

The effects of scopolamine on sleep and mood in depressed patients with a history of alcoholism and a normal comparison group

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

M1 and m2 muscarinic receptor subtypes regulate antidepressant-like effects of the rapidly acting antidepressant scopolamine

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Activation of the mTOR signaling pathway in the antidepressant-like activity of the mGlu5 antagonist MTEP and the mGlu7 agonist AMN082 in the FST in rats

27 October 2018

1 reference

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Brain damages in ketamine addicts as revealed by magnetic resonance imaging

27 October 2018

1 reference

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Surveillance for violent deaths--National Violent Death Reporting System, 16 states, 2009.

27 October 2018

1 reference

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Involvement of mGlu5 and NMDA receptors in the antidepressant-like effect of acamprosate in the tail suspension test

27 October 2018

1 reference

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Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD.

27 October 2018

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Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults

27 October 2018

1 reference

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Blocking the deadly effects of the NMDA receptor in stroke.

27 October 2018

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Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression

27 October 2018

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Stressor-specific regulation of distinct brain-derived neurotrophic factor transcripts and cyclic AMP response element-binding protein expression in the postnatal and adult rat hippocampus

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

A double-blind, placebo-controlled study of memantine in the treatment of major depression

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

In vivo labelling of alpha5 subunit-containing GABA(A) receptors using the selective radioligand [(3)H]L-655,708.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Limbic-cortical dysregulation: a proposed model of depression

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Heterogeneous Targets of Dopamine Synapses in Monkey Prefrontal Cortex Demonstrated by Serial Section Electron Microscopy: A Laminar Analysis Using the Silver-enhanced Diaminobenzidine Sulfide (SEDS) Immunolabeling Technique

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4803609

Clinical effects of amitriptyline in adolescent depression. A pilot study

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26854424

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cyloserine as an antidepressant agent

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26854424

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.DRUDIS.2016.01.016

1 reference

2 August 2017

1 reference

2 August 2017

1 reference