Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy (Q34482623)

2 August 2017

title

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy (English)

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2 August 2017

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Esperanza Arias

1

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Ana María Cuervo

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Ana María Cuervo

6

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author name string

Hiroshi Koga

2

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2 August 2017

Antonio Diaz

3

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2 August 2017

Enric Mocholi

4

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2 August 2017

Bindi Patel

5

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2 August 2017

publication date

25 June 2015

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2 August 2017

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2 August 2017

volume

59

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2 August 2017

issue

2

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2 August 2017

page(s)

270-284

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Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage

2 August 2017

cites work

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Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation

6 July 2018

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IGF-1 receptor antagonism inhibits autophagy

6 July 2018

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Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation

6 July 2018

1 reference

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Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation

6 July 2018

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Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.

6 July 2018

1 reference

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Chaperone-mediated autophagy: a unique way to enter the lysosome world

6 July 2018

1 reference

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Regulation of TOR by small GTPases

6 July 2018

1 reference

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Chaperone-mediated autophagy is required for tumor growth

6 July 2018

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Rapamycin passes the torch: a new generation of mTOR inhibitors

6 July 2018

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A photoconvertible fluorescent reporter to track chaperone-mediated autophagy

6 July 2018

1 reference

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Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size

6 July 2018

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Lysosomal positioning coordinates cellular nutrient responses.

6 July 2018

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Autophagy and the Integrated Stress Response

6 July 2018

1 reference

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Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening

6 July 2018

1 reference

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Identification of regulators of chaperone-mediated autophagy

6 July 2018

1 reference

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

6 July 2018

1 reference

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Methods to monitor chaperone-mediated autophagy

6 July 2018

1 reference

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The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

6 July 2018

1 reference

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Autophagy fights disease through cellular self-digestion

6 July 2018

1 reference

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The phosphatase PHLPP controls the cellular levels of protein kinase C

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

Consequences of the selective blockage of chaperone-mediated autophagy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

6 July 2018

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

Activation of chaperone-mediated autophagy during oxidative stress

6 July 2018

1 reference

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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

6 July 2018

1 reference

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An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

A receptor for the selective uptake and degradation of proteins by lysosomes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation

6 July 2018

1 reference

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A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

6 July 2018

1 reference

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Isolation of subcellular organelles

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506737

10.1016/J.MOLCEL.2015.05.030

27 October 2018

Identifiers

DOI

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2 August 2017

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2 August 2017

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