Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing. (Q34457002)

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English	Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing.	scientific article

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7 January 2020

Essential role of obscurin in cardiac myofibrillogenesis and hypertrophic response: evidence from small interfering RNA-mediated gene silencing (English)

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7 January 2020

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Margaret V Westfall

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7 January 2020

Aikaterini Kontrogianni-Konstantopoulos

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Aikaterini Kontrogianni-Konstantopoulos

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7 January 2020

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Andrei B Borisov

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7 January 2020

Sarah B Sutter

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7 January 2020

Robert J Bloch

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7 January 2020

Mark W Russell

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7 January 2020

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5 October 2005

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7 January 2020

Histochemistry and Cell Biology

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7 January 2020

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7 January 2020

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7 January 2020

227-238

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7 January 2020

Small guanine nucleotide-binding proteins and myocardial hypertrophy

1 reference

https://api.crossref.org/works/10.1007%2FS00418-005-0069-X

21 January 2018

Myofibrillogenesis in the first cardiomyocytes formed from isolated quail precardiac mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient generation of recombinant adenoviral vectors by Cre-lox recombination in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New approaches to phenotypic analysis in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification, tissue expression and chromosomal localization of human Obscurin-MLCK, a member of the titin and Dbl families of myosin light chain kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho and Rac take center stage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle assembly: a titanic achievement?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desmin: a major intermediate filament protein essential for the structural integrity and function of muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA interference: past, present and future.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of gene function in somatic mammalian cells using small interfering RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thick filament assembly occurs after the formation of a cytoskeletal scaffold.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antisense oligonucleotide experiments elucidate the essential role of titin in sarcomerogenesis in adult rat cardiomyocytes in long-term culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling Pathways in Cardiac Myocyte Hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myofibrillogenesis and reversible disassembly of myofibrills as adaptive reactions of cardiac muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sarcomere number regulation maintained after immobilization in desmin-null mouse skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fishing out proteins that bind to titin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sarcomeric genotyping in hypertrophic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soaking up RNAi

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

M-band: a safeguard for sarcomere stability?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties of titin immunoglobulin and fibronectin-3 domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerisation of myomesin: implications for the structure of the sarcomeric M-band

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

siRNAs: applications in functional genomics and potential as therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

OrthoDisease: a database of human disease orthologs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Caenorhabditis elegans gene unc-89, required fpr muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene silencing using adenoviral RNAi vector in vascular smooth muscle cells and cardiomyocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biology of desmin filaments: how do mutations affect their structure, assembly, and organisation?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perspective: machines for RNAi

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA interference and the use of small interfering RNA to study gene function in mammalian systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nemaline myopathy in the Ashkenazi Jewish population is caused by a deletion in the nebulin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desmin in muscle formation and maintenance: knockouts and consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel troponin T mutation in familial dilated cardiomyopathy with gender-dependant severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obscurin regulates the organization of myosin into A bands

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PEVK extension of human soleus muscle titin revealed by immunolabeling with the anti-titin antibody 9D10

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in alpha-actinin localization and myofibrillogenesis in rat cardiomyocytes under cultivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocyte hypertrophy: the long and winding RhoA'd

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies to the muscle isoform of alpha-actinin--a marker for the study of the differentiation of skeletal and cardiac muscles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular engineering of ventricular adult rat cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of alpha adrenergic stimulation and carnitine palmitoyl transferase I inhibition on hypertrophying adult rat cardiomyocytes in culture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the muscle LIM protein and α-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult rat cardiomyocytes in culture A model system to study the plasticity of the differentiated cardiac phenotype at the molecular and cellular levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desmin-related myopathies in mice and man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A targeted deletion of the C-terminal end of titin, including the titin kinase domain, impairs myofibrillogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of the interaction between titin and myosin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defining and assaying RNAi in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Independent assembly of 1.6 microns long bipolar MHC filaments and I-Z-I bodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obscurin is a ligand for small ankyrin 1 in skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of Z-band based proteins in developing skeletal muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Null mutation in the desmin gene gives rise to a cardiomyopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sensitive giant: the role of titin-based stretch sensing complexes in the heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomewide view of gene silencing by small interfering RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weakness of a giant: mutations of the sarcomeric protein titin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myofilament protein phosphorylation by PKC in genetically engineered adult cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myomesin is a molecular spring with adaptable elasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle disease: a giant feels the strain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nebulin: the nebulous, multifunctional giant of striated muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene silencing by adenovirus-delivered siRNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Titin mutations as the molecular basis for dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RNA interference: historical overview and significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of obscurin localization during differentiation and remodeling of cardiac myocytes: obscurin as an integrator of myofibrillar structure

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New concepts in hypertrophic cardiomyopathies, part I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Titin: properties and family relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A functional knock-out of titin results in defective myofibril assembly.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of heparin-binding epidermal growth factor-like growth factor mRNA levels by hypertrophic stimuli in neonatal and adult rat cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Titin domain patterns correlate with the axial disposition of myosin at the end of the thick filament.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triiodothyronine restricts myofibrillar growth and enhances beating frequency in cultured adult rat cardiomyocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac troponin T is essential in sarcomere assembly and cardiac contractility

1 reference

https://pubmed.ncbi.nlm.nih.gov/16205939

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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