Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting. (Q34407398)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21158687%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting (English)

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18 January 2020

0 references

1 reference

1

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18 January 2020

author name string

Thomas Mangano

2

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18 January 2020

Sandy Hufeisen

3

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18 January 2020

Vincent Setola

4

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18 January 2020

Bryan L Roth

5

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18 January 2020

publication date

1 December 2010

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Assay and Drug Development Technologies

18 January 2020

published in

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18 January 2020

volume

8

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18 January 2020

issue

6

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18 January 2020

page(s)

727-742

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Cell-based potassium ion channel screening using the FluxOR assay

18 January 2020

cites work

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Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels

6 July 2018

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Hsp40 chaperones promote degradation of the HERG potassium channel

6 July 2018

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PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance

6 July 2018

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Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A.

6 July 2018

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Extracellular K+ concentration controls cell surface density of IKr in rabbit hearts and of the HERG channel in human cell lines

6 July 2018

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A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

6 July 2018

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HERG1 gene expression as a specific tumor marker in colorectal tissues

6 July 2018

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Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives

6 July 2018

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State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy

6 July 2018

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PKA phosphorylation of HERG protein regulates the rate of channel synthesis.

6 July 2018

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Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction

6 July 2018

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Collation, assessment and analysis of literature in vitro data on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

6 July 2018

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Cardiotoxicity after massive amantadine overdose

6 July 2018

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Cellular basis of drug-induced torsades de pointes

6 July 2018

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hERG channel trafficking: novel targets in drug-induced long QT syndrome

6 July 2018

1 reference

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Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

6 July 2018

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Can pharmacogenetics help rescue drugs withdrawn from the market?

6 July 2018

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Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

6 July 2018

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Electrical alternans and hemodynamics in the anesthetized guinea pig can discriminate the cardiac safety of antidepressants.

6 July 2018

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hERG potassium channels and cardiac arrhythmia

6 July 2018

1 reference

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HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

6 July 2018

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Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature

6 July 2018

1 reference

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Pentamidine reduces hERG expression to prolong the QT interval

6 July 2018

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A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel modulators in mammalian cells

6 July 2018

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The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o

6 July 2018

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QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development

6 July 2018

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Validation of a [3H]astemizole binding assay in HEK293 cells expressing HERG K+ channels

6 July 2018

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HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery.

6 July 2018

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Phenytoin and phenobarbital inhibit human HERG potassium channels

6 July 2018

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6 July 2018

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6 July 2018

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BeKm-1 Is a HERG-Specific Toxin that Shares the Structure with ChTx but the Mechanism of Action with ErgTx1

6 July 2018

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A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels

6 July 2018

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[3H]dofetilide binding in SHSY5Y and HEK293 cells expressing a HERG-like K+ channel?

6 July 2018

1 reference

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A structural basis for drug-induced long QT syndrome

6 July 2018

1 reference

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Inhibition of delayed rectifier K+ channels by phenytoin in rat neuroblastoma cells

6 July 2018

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A family of potassium channel genes related to eag in Drosophila and mammals

6 July 2018

1 reference

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A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

6 July 2018

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

6 July 2018

1 reference

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Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

6 July 2018

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Improved throughput of PatchXpress hERG assay using intracellular potassium fluoride

27 October 2018

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In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation

27 October 2018

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Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking

27 October 2018

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Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity

27 October 2018

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Pentamidine-induced long QT syndrome and block of hERG trafficking

27 October 2018

1 reference

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Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

27 October 2018

1 reference

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Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG.

27 October 2018

1 reference

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Effects of fluoroquinolones on HERG currents

27 October 2018

1 reference

12 December 2020

A high-throughput HERG potassium channel function assay: an old assay with a new look

1 reference

12 December 2020

High-Throughput Screening for Ion Channel Modulators

1 reference

12 December 2020

Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern

1 reference

12 December 2020

Inversion of the intracellular Na+/K+ ratio blocks apoptosis in vascular smooth muscle at a site upstream of caspase-3

1 reference

12 December 2020

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12 December 2020

Identifiers

DOI

10.1089/ADT.2010.0331

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21158687%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21158687%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

PubMed publication ID

21158687

1 reference