Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus. (Q34388621)

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21 February 2020

title

Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus (English)

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21 February 2020

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2

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21 February 2020

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Amato J Giaccia

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21 February 2020

author name string

Christophe Merceron

1

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21 February 2020

Alexander Robling

3

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21 February 2020

Tremika LeShan Wilson

4

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21 February 2020

Irving M Shapiro

6

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21 February 2020

Ernestina Schipani

7

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21 February 2020

Makarand V Risbud

8

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21 February 2020

language of work or name

English

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publication date

22 October 2014

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21 February 2020

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21 February 2020

volume

9

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21 February 2020

issue

10

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21 February 2020

page(s)

e110768

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Creative Commons Attribution 4.0 International

21 February 2020

copyright license

start time

22 October 2014

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Advancing the cellular and molecular therapy for intervertebral disc disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Impaired intervertebral disc development and premature disc degeneration in mice with notochord-specific deletion of CCN2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Hypoxia-driven pathways in bone development, regeneration and disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Structure and biology of the intervertebral disk in health and disease.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Toward an understanding of the role of notochordal cells in the adult intervertebral disc: from discord to accord

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Identification of nucleus pulposus precursor cells and notochordal remnants in the mouse: implications for disk degeneration and chordoma formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Intervertebral disc: anatomy-physiology-pathophysiology-treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

A global double-fluorescent Cre reporter mouse

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

What is intervertebral disc degeneration, and what causes it?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Nutrient supply and intervertebral disc metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Hypoxia and HIF-1alpha in osteoarthritis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Nutrition of the intervertebral disc

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4206488

Phenotypic characteristics of the nucleus pulposus: expression of hypoxia inducing factor-1, glucose transporter-1 and MMP-2.

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110768

Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110768

Vertebral endplate architecture and vascularization: application of micro-computerized tomography, a vascular tracer, and immunocytochemistry in analyses of disc degeneration in the aging sand rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110768

HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110768

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110768

The Human Intervertebral Disc: A Micro-Angiographical Study on Its Vascular Supply at Various Ages

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110768

Expression of Fas ligand and apoptosis of disc cells in herniated lumbar disc tissue

21 January 2018

1 reference

12 December 2020

Lymph and blood supply of the human intervertebral disc. Cadaver study of correlations to discitis

1 reference

12 December 2020

Mechanoreceptors in intervertebral discs. Morphology, distribution, and neuropeptides

1 reference

12 December 2020

Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk

1 reference

12 December 2020

Cited2 modulates hypoxia-inducible factor-dependent expression of vascular endothelial growth factor in nucleus pulposus cells of the rat intervertebral disc

1 reference

12 December 2020

The intervertebral disc: From pathophysiology to tissue engineering

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0110768

Identifiers

DOI

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21 February 2020

0 references

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21 February 2020

PubMed publication ID

25338007

1 reference

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