Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier (Q34367048)

1 August 2017

title

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier (English)

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1 August 2017

Kim A Lennox

1

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1 August 2017

Richard Owczarzy

2

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1 August 2017

Derek M Thomas

3

1 reference

1 August 2017

Joseph A Walder

4

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1 August 2017

Mark A Behlke

5

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1 August 2017

publication date

27 August 2013

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Molecular Therapy. Nucleic acids

1 August 2017

published in

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1 August 2017

volume

2

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1 August 2017

page(s)

e117

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Chemical modification study of antisense gapmers

1 August 2017

cites work

1 reference

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Inhibition of microRNA function by antimiR oligonucleotides

6 July 2018

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Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

6 July 2018

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Chemical modification and design of anti-miRNA oligonucleotides.

6 July 2018

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Silencing of microRNA families by seed-targeting tiny LNAs

6 July 2018

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Optical Melting Measurements of Nucleic Acid Thermodynamics

6 July 2018

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miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate

6 July 2018

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Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

6 July 2018

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Off-target effects related to the phosphorothioate modification of nucleic acids.

6 July 2018

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A direct comparison of anti-microRNA oligonucleotide potency.

6 July 2018

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Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF

6 July 2018

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Origins and Mechanisms of miRNAs and siRNAs

6 July 2018

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Therapeutic potential of splice-switching oligonucleotides

6 July 2018

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Potent inhibition of microRNA in vivo without degradation

6 July 2018

1 reference

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LNA-mediated microRNA silencing in non-human primates

6 July 2018

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Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

6 July 2018

1 reference

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miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates

6 July 2018

1 reference

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Specificity, duplex degradation and subcellular localization of antagomirs

6 July 2018

1 reference

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Capillary electrophoresis is a sensitive monitor of the hairpin-random coil transition in DNA oligomers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Double-stranded regions are essential design components of potent inhibitors of RISC function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

6 July 2018

1 reference

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Probing enzyme phosphoester interactions by combining mutagenesis and chemical modification of phosphate ester oxygens

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Improved targeting of miRNA with antisense oligonucleotides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Silencing of microRNAs in vivo with 'antagomirs'

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Pharmacokinetic properties of 2'-O-(2-methoxyethyl)-modified oligonucleotide analogs in rats

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Mechanism and function of a newly identified CpG DNA motif in human primary B cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Self-stabilized antisense oligodeoxynucleotide phosphorothioates: properties and anti-HIV activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Backbone modifications in oligonucleotides and peptide nucleic acid systems

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Substrate Specificity and Kinetics of Degradation of Antisense Oligonucleotides by a 3′ Exonuclease in Plasma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Stereochemistry of hydrolysis by snake venom phosphodiesterase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

MiRNA activity directs stem cell commitment to a particular fate

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Effects of sodium ions on DNA duplex oligomers: improved predictions of melting temperatures.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3759741

Characterization of modified antisense oligonucleotides in Xenopus laevis embryos

27 October 2018

1 reference

12 December 2020

Phosphorothioate oligodeoxynucleotides: antisense or anti-protein?

1 reference

12 December 2020

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys

1 reference

12 December 2020

Thermodynamics of the Helix-Coil Transition of (dG-dC) Oligomers

1 reference

12 December 2020

Identifiers

DOI

10.1038/MTNA.2013.46

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1 August 2017

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1 August 2017

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