Metformin improves healthspan and lifespan in mice (Q34360789)

1 August 2017

title

Metformin improves healthspan and lifespan in mice (English)

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1 August 2017

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Morten Scheibye-Knudsen

Morten Scheibye-Knudsen

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Michel Bernier

Michel Bernier

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Rafael de Cabo

Rafael de Cabo

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Vilhelm A. Bohr

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Vilhelm A Bohr

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1 August 2017

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Donald K Ingram

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1 August 2017

author name string

Alejandro Martin-Montalvo

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Evi M Mercken

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Sarah J Mitchell

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Hector H Palacios

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Patricia L Mote

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Ana P Gomes

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Theresa M Ward

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Robin K Minor

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Marie-José Blouin

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Matthias Schwab

11

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Michael Pollak

12

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Yongqing Zhang

13

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Yinbing Yu

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Norman S Wolf

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Stephen R Spindler

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language of work or name

English

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publication date

1 January 2013

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1 August 2017

published in

Nature Communications

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1 August 2017

volume

4

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1 August 2017

page(s)

2192

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Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

1 August 2017

cites work

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6 July 2018

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Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects

6 July 2018

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6 July 2018

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Distinct perturbation of the translatome by the antidiabetic drug metformin

6 July 2018

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6 July 2018

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Fatty acids revert the inhibition of respiration caused by the antidiabetic drug metformin to facilitate their mitochondrial β-oxidation.

6 July 2018

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6 July 2018

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Metformin reduces endogenous reactive oxygen species and associated DNA damage

6 July 2018

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Prebiotic fiber increases hepatic acetyl CoA carboxylase phosphorylation and suppresses glucose-dependent insulinotropic polypeptide secretion more effectively when used with metformin in obese rats

6 July 2018

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Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

6 July 2018

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Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

6 July 2018

1 reference

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Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein

6 July 2018

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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

6 July 2018

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Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

6 July 2018

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NRF2, cancer and calorie restriction

6 July 2018

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Changes in Weight at the End of Life: Characterizing Weight Loss by Time to Death in a Cohort Study of Older Men

6 July 2018

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AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3).

6 July 2018

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Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

6 July 2018

1 reference

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Diabetes and cancer: a consensus report.

6 July 2018

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Metformin supplementation and life span in Fischer-344 rats

6 July 2018

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The nuclear factor-kappaB-interleukin-6 signalling pathway mediating vascular inflammation.

6 July 2018

1 reference

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Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

6 July 2018

1 reference

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

6 July 2018

1 reference

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Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein

6 July 2018

1 reference

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Oxidative stress mediated cytotoxicity of cyanide in LLC-MK2 cells and its attenuation by alpha-ketoglutarate and N-acetyl cysteine

6 July 2018

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Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview

6 July 2018

1 reference

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

6 July 2018

1 reference

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Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Resveratrol improves health and survival of mice on a high-calorie diet

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Identification of potential caloric restriction mimetics by microarray profiling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

PAGE: parametric analysis of gene set enrichment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Metformin and its liver targets in the treatment of type 2 diabetes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Analysis of microarray data using Z score transformation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Role of AMP-activated protein kinase in mechanism of metformin action

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Metformin-associated lactic acidosis: incidence, diagnosis, prognostic factors and treatment

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Use of microarray biomarkers to identify longevity therapeutics

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736576

[Metformin associated with lactic acidosis in treatment of type 2 diabetes]

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23900241

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The effect of intravenous metformin on glucose metabolism during hyperglycaemia in type 2 diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23900241

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inflammation and insulin resistance

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23900241

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS3192

1 reference

Dimensions Publication ID

1 August 2017

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1 August 2017

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