The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells (Q34310345)

1 August 2017

title

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells (English)

1 reference

1 August 2017

Sian M Henson

2

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Arne N Akbar

object named as

Arne N Akbar

series ordinal

4

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David Escors

object named as

David Escors

series ordinal

3

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author name string

Alessio Lanna

series ordinal

1

1 reference

1 August 2017

language of work or name

English

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publication date

24 August 2014

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1 August 2017

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1 August 2017

volume

15

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1 August 2017

issue

10

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1 August 2017

page(s)

965-972

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Counter-regulation of T cell effector function by differentially activated p38.

1 August 2017

cites work

1 reference

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Genetic disruption of p38alpha Tyr323 phosphorylation prevents T-cell receptor-mediated p38alpha activation and impairs interferon-gamma production

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase

6 July 2018

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Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors

6 July 2018

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Oxygen free radicals in cell senescence: are they signal transducers?

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

6 July 2018

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Telomere erosion in memory T cells induced by telomerase inhibition at the site of antigenic challenge in vivo

6 July 2018

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T cell receptor signaling: beyond complex complexes

6 July 2018

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CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation

6 July 2018

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TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1

6 July 2018

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6 July 2018

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MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

6 July 2018

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Mammalian MAP kinase signalling cascades

6 July 2018

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Inhibition of p38 MAP kinase as a therapeutic strategy

6 July 2018

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TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Will telomere erosion lead to a loss of T-cell memory?

6 July 2018

1 reference

Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion

21 January 2018

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KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells.

21 January 2018

1 reference

Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process

21 January 2018

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Reversible senescence in human CD4+CD45RA+CD27- memory T cells

21 January 2018

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MAPK p38: alternative and nonstressful in T cells

21 January 2018

1 reference

The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation

21 January 2018

1 reference

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart

21 January 2018

1 reference

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

21 January 2018

1 reference

IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4190666

Choreography of MAGUKs during T cell activation

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25151490

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25151490

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.2981

1 reference

Dimensions Publication ID

1 August 2017

0 references

1 reference

1 August 2017

1 reference