Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors (Q34263558)

1 August 2017

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title

Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors (English)

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1 August 2017

Burke TR Jr

1

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1 August 2017

Yao ZJ

2

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1 August 2017

Liu DG

3

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1 August 2017

Voigt J

4

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1 August 2017

Gao Y

5

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1 August 2017

publication date

1 January 2001

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1 August 2017

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1 August 2017

volume

60

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1 August 2017

issue

1

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1 August 2017

page(s)

32-44

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Cell signalling and the control of gene transcription.

1 August 2017

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21 January 2018

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A new flavor in phosphotyrosine recognition

21 January 2018

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Protein modules and signalling networks

21 January 2018

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From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'.

21 January 2018

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Protein tyrosine phosphatases: mechanisms of catalysis and regulation

21 January 2018

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The structure and mechanism of protein phosphatases: insights into catalysis and regulation

21 January 2018

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Intracellular receptors and signal transducers and activators of transcription superfamilies: novel targets for small-molecule drug discovery

21 January 2018

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Targeting signal transduction for disease therapy

21 January 2018

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Targeting signal transduction in the discovery of antiproliferative drugs

21 January 2018

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Novel anticancer drug discovery

21 January 2018

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The development and therapeutic potential of protein kinase inhibitors

21 January 2018

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Protein tyrosine kinase inhibitors as novel therapeutic agents

21 January 2018

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SH2 and SH3 domains: potential targets for anti-cancer drug design

21 January 2018

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SH2 domain protein interaction and possibilities for pharmacological intervention

21 January 2018

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SH2 and PTB domain interactions in tyrosine kinase signal transduction.

21 January 2018

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

21 January 2018

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Crystal structure of the tyrosine kinase domain of the human insulin receptor

21 January 2018

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Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

21 January 2018

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Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

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Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

21 January 2018

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Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

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Protein kinase inhibitors: the tyrosine-specific protein kinases

21 January 2018

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Identification of GIYWHHY as a novel peptide substrate for human p60c-src protein tyrosine kinase

21 January 2018

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Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design

21 January 2018

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Recognition and regulation of primary-sequence motifs by signaling modular domains

21 January 2018

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Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

21 January 2018

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Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

21 January 2018

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SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships

21 January 2018

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Thermodynamic and structural analysis of phosphotyrosine polypeptide binding to Grb2-SH2

21 January 2018

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Diversity in protein recognition by PTB domains

21 January 2018

1 reference

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Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins

21 January 2018

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Structure and ligand recognition of the phosphotyrosine binding domain of Shc

21 January 2018

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Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

21 January 2018

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Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B

21 January 2018

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Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide

21 January 2018

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Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors.

21 January 2018

1 reference

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Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking

21 January 2018

1 reference

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Selective GRB2 SH2 inhibitors as anti-Ras therapy

21 January 2018

1 reference

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Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic

21 January 2018

1 reference

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Potent blockade of hepatocyte growth factor-stimulated cell motility, matrix invasion and branching morphogenesis by antagonists of Grb2 Src homology 2 domain interactions

21 January 2018

1 reference

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Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding

21 January 2018

1 reference

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Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates

21 January 2018

1 reference

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Ligands for the Tyrosine Kinase p56lckSH2 Domain: Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements

21 January 2018

1 reference

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Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase

21 January 2018

1 reference

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Novel phosphotyrosine mimetics in the design of peptide ligands for pp60src SH2 domain

21 January 2018

1 reference

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The Role of 4-phosphonodifluoromethyl- and 4-phosphono-phenylalanine in the selectivity and cellular uptake of SH2 domain ligands

21 January 2018

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Signal transduction as a drug-discovery platform

21 January 2018

1 reference

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Nonphosphorylatable tyrosine surrogates. Implications for protein kinase inhibitor design

21 January 2018

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Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery

21 January 2018

1 reference

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The design, synthesis and activity of pentapeptide pp60c-src inhibitors containing L-phosphotyrosine mimics

21 January 2018

1 reference

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Cyclic peptides incorporating 4-carboxyphenylalanine and phosphotyrosine are potent inhibitors of pp60(c-)(src)

21 January 2018

1 reference

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How and why phosphotyrosine-containing peptides bind to the SH2 and PTB domains

21 January 2018

1 reference

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Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands

21 January 2018

1 reference

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L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides

21 January 2018

1 reference

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Examination of novel non-phosphorus-containing phosphotyrosyl mimetics against protein-tyrosine phosphatase-1B and demonstration of differential affinities toward Grb2 SH2 domains

21 January 2018

1 reference

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Potent Inhibition of Insulin Receptor Dephosphorylation by a Hexamer Peptide Containing the Phosphotyrosyl Mimetic F2Pmp

21 January 2018

1 reference

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Protein-tyrosine phosphatase inhibition by a peptide containing the phosphotyrosyl mimetic, L-O-malonyltyrosine

21 January 2018

1 reference

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4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides

21 January 2018

1 reference

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Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

21 January 2018

1 reference

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Structure-based discovery of small molecule inhibitors targeted to protein tyrosine phosphatase 1B

21 January 2018

1 reference

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10.1002/1097-0282(2001)60:1<32::AID-BIP1002>3.0.CO;2-I

21 January 2018

Identifiers

DOI

1 reference

1 August 2017

1 reference