Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation (Q34254827)

31 July 2017

title

Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation (English)

1 reference

31 July 2017

3

Lance Davidow

1 reference

31 July 2017

8

Lee L Rubin

1 reference

31 July 2017

Yu Wang

1

1 reference

31 July 2017

Anthony C Arvanites

2

1 reference

31 July 2017

Joel Blanchard

4

1 reference

31 July 2017

Kelvin Lam

5

1 reference

31 July 2017

Jin Woo Yoo

6

1 reference

31 July 2017

Shannon Coy

7

1 reference

31 July 2017

Andrew P McMahon

9

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31 July 2017

publication date

3 May 2012

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31 July 2017

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31 July 2017

volume

7

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31 July 2017

issue

6

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31 July 2017

page(s)

1040-1048

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Hedgehog hopes lifted by approval... and stung by failure

31 July 2017

cites work

1 reference

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Sequential phosphorylation of smoothened transduces graded hedgehog signaling.

6 July 2018

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Sonic Hedgehog dependent phosphorylation by CK1α and GRK2 is required for ciliary accumulation and activation of smoothened

6 July 2018

1 reference

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Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

6 July 2018

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Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

6 July 2018

1 reference

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6 July 2018

1 reference

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

6 July 2018

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

6 July 2018

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

6 July 2018

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6 July 2018

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Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium

6 July 2018

1 reference

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Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

6 July 2018

1 reference

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Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process

6 July 2018

1 reference

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Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

6 July 2018

1 reference

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A paracrine requirement for hedgehog signalling in cancer

6 July 2018

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Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

6 July 2018

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Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

6 July 2018

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Potent inhibitors of the hedgehog signaling pathway.

6 July 2018

1 reference

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Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms

6 July 2018

1 reference

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Patched1 regulates hedgehog signaling at the primary cilium

6 July 2018

1 reference

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Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

6 July 2018

1 reference

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Cholesterol modification restricts the spread of Shh gradient in the limb bud.

6 July 2018

1 reference

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Vertebrate Smoothened functions at the primary cilium

6 July 2018

1 reference

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Identification of an agonist ligand for estrogen-related receptors ERRbeta/gamma.

6 July 2018

1 reference

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Microtubules as a target for anticancer drugs

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Wnt proteins are lipid-modified and can act as stem cell growth factors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Developmental roles and clinical significance of hedgehog signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Small molecule modulation of Smoothened activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Cholesterol in signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Activating Smoothened mutations in sporadic basal-cell carcinoma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3905677

Targeting the Hedgehog pathway in cancer

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22554036

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CB300028A

1 reference

31 July 2017

1 reference

31 July 2017

1 reference