Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools (Q34237641)

31 July 2017

title

Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools (English)

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31 July 2017

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4

Christina D Smolke

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31 July 2017

Michael S Siddiqui

1

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31 July 2017

Kate Thodey

series ordinal

2

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31 July 2017

Isis Trenchard

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3

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31 July 2017

language of work or name

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11 January 2012

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31 July 2017

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31 July 2017

volume

12

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31 July 2017

issue

2

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31 July 2017

page(s)

144-170

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Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes

31 July 2017

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Production of resveratrol in recombinant microorganisms

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Microbial production of natural raspberry ketone

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Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms.

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Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae

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Organization of intracellular reactions with rationally designed RNA assemblies

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Reengineering orthogonally selective riboswitches

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Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model

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Synthetic protein scaffolds provide modular control over metabolic flux.

21 January 2018

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11 beta-hydroxylase activity in recombinant yeast mitochondria. In vivo conversion of 11-deoxycortisol to hydrocortisone.

21 January 2018

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Self-sufficient biosynthesis of pregnenolone and progesterone in engineered yeast

21 January 2018

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Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast

21 January 2018

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Quality and authenticity of heterologous proteins synthesized in yeast

21 January 2018

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Engineering of polyploid Saccharomyces cerevisiae for secretion of large amounts of fungal glucoamylase

21 January 2018

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In vitro selection of RNA molecules that bind specific ligands

21 January 2018

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Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

21 January 2018

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Production of tranilast [N-(3',4'-dimethoxycinnamoyl)-anthranilic acid] and its analogs in yeast Saccharomyces cerevisiae

21 January 2018

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A vector set for systematic metabolic engineering in Saccharomyces cerevisiae

21 January 2018

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Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Enzymatic assembly of overlapping DNA fragments

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

A synthetic gene network for tuning protein degradation in Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Codon bias and heterologous protein expression

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

A family of destabilized cyan fluorescent proteins as transcriptional reporters in S. cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae

21 January 2018

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Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Polycistronic gene expression in yeast versus cryptic promoter elements

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Internal ribosome entry sites in eukaryotic mRNA molecules

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Engineering the Saccharomyces cerevisiae isoprenoid pathway for de novo production of aromatic monoterpenes in wine

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Diamonds are forever: the cortisone legacy

21 January 2018

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DNAWorks: an automated method for designing oligonucleotides for PCR-based gene synthesis

21 January 2018

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Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster

21 January 2018

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High-resolution molecular discrimination by RNA.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis

21 January 2018

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The level of glucose‐6‐phosphate dehydrogenase activity strongly influences xylose fermentation and inhibitor sensitivity in recombinant Saccharomyces cerevisiae strains

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Metabolic engineering of the phenylpropanoid pathway in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Metabolon formation and metabolic channeling in the biosynthesis of plant natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Pheromones, social behaviour and the functions of secondary metabolism in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Application of functional genomics to pathway optimization for increased isoprenoid production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Total synthesis of long DNA sequences: synthesis of a contiguous 32-kb polyketide synthase gene cluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Specific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Sequential δ‐Integration for the Regulated Insertion of Cloned Genes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Improved efficiency and stability of multiple cloned gene insertions at the δ sequences of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Application of sequential integration for metabolic engineering of 1,2-propanediol production in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Investigation of two distinct flavone synthases for plant-specific flavone biosynthesis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Functional expression of a P450 flavonoid hydroxylase for the biosynthesis of plant-specific hydroxylated flavonols in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Strain improvement of recombinant Escherichia coli for efficient production of plant flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Engineering Biological Systems with Synthetic RNA Molecules

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Complete reconstitution of a highly reducing iterative polyketide synthase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Destabilized green fluorescent protein for monitoring dynamic changes in yeast gene expression with flow cytometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Reconstruction of a bacterial isoprenoid biosynthetic pathway in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Microbial production of plant benzylisoquinoline alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Combinatorial biosynthesis of flavones and flavonols in Escherichia coli.

21 January 2018

1 reference

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Production of novel antioxidative phenolic amides through heterologous expression of the plant's chlorogenic acid biosynthesis genes in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression

21 January 2018

1 reference

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Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds

21 January 2018

1 reference

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Metabolic pathway engineering for complex polyketide biosynthesis in Saccharomyces cerevisiae.

21 January 2018

1 reference

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Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

A bacterial platform for fermentative production of plant alkaloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Production of geranylgeraniol on overexpression of a prenyl diphosphate synthase fusion gene in Saccharomyces cerevisiae

21 January 2018

1 reference

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Development of stable flocculent Saccharomyces cerevisiae strain for continuous Aspergillus niger beta-galactosidase production

21 January 2018

1 reference

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Engineering of yeast Put4 permease and its application to lager yeast for efficient proline assimilation

21 January 2018

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Monoterpenoid biosynthesis in Saccharomyces cerevisiae

21 January 2018

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Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase

21 January 2018

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Vector systems for the expression, analysis and cloning of DNA sequences in S. cerevisiae

21 January 2018

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Characterization of different promoters for designing a new expression vector in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Production of the potent antibacterial polyketide erythromycin C in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Genetics and biochemistry of secondary metabolites in plants: an evolutionary perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Yeast expression of animal and plant P450s in optimized redox environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Partial reconstruction of flavonoid and isoflavonoid biosynthesis in yeast using soybean type I and type II chalcone isomerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Targeted proteomics for metabolic pathway optimization: application to terpene production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Oligo- and poly-nucleotides: 50 years of chemical synthesis

21 January 2018

1 reference

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Enhanced production of a plant monoterpene by overexpression of the 3-hydroxy-3-methylglutaryl coenzyme A reductase catalytic domain in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Reconstitution of the entry point of plant phenylpropanoid metabolism in yeast (Saccharomyces cerevisiae): implications for control of metabolic flux into the phenylpropanoid pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

CYP725A4 from yew catalyzes complex structural rearrangement of taxa-4(5),11(12)-diene into the cyclic ether 5(12)-oxa-3(11)-cyclotaxane.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Compartmentalization and molecular traffic in secondary metabolism: a new understanding of established cellular processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Eukaryotic transcription factors as direct nutrient sensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Expression of a plant viral polycistronic mRNA in yeast, Saccharomyces cerevisiae, mediated by a plant virus translational transactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Engineering of the pyruvate dehydrogenase bypass in Saccharomyces cerevisiae for high-level production of isoprenoids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Total biosynthesis of hydrocortisone from a simple carbon source in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Production of p-hydroxycinnamic acid from glucose in Saccharomyces cerevisiae and Escherichia coli by expression of heterologous genes from plants and fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Biotechnology of flavonoids and other phenylpropanoid-derived natural products. Part I: Chemical diversity, impacts on plant biology and human health.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

21 January 2018

Life from information

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Optimization of heterologous production of the polyketide 6-MSA in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Exploring recombinant flavonoid biosynthesis in metabolically engineered Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Why are secondary metabolites (natural products) biosynthesized?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

A modular and extensible RNA-based gene-regulatory platform for engineering cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Codeine-binding RNA aptamers and rapid determination of their binding constants using a direct coupling surface plasmon resonance assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Reiterative Recombination for the in vivo assembly of libraries of multigene pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Doxycycline, the drug used to control the tet-regulatable promoter system, has no effect on global gene expression in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in Vitro and in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Biosynthesis of natural flavanones in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Biosynthesis of 5-deoxyflavanones in microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Using unnatural protein fusions to engineer resveratrol biosynthesis in yeast and Mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Transcript leader regions of two Saccharomyces cerevisiae mRNAs contain internal ribosome entry sites that function in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Isolation and identification of short nucleotide sequences that affect translation initiation in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1567-1364.2011.00774.X

10.1111/J.1567-1364.2011.00774.X

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference