Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent (Q34199557)

31 July 2017

title

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent (English)

1 reference

31 July 2017

0 references

1 reference

1 reference

8

Toren Finkel

1 reference

31 July 2017

1

Andrey Parkhitko

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

6 December 2024

author name string

Faina Myachina

2

1 reference

31 July 2017

Neil Auricchio

5

1 reference

31 July 2017

Magdalena Karbowniczek

6

1 reference

31 July 2017

Elizabeth Petri Henske

11

1 reference

31 July 2017

Tasha A. Morrison

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

6 December 2024

Khadijah M. Hindi

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

6 December 2024

J. Julia Wu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

6 December 2024

David J. Kwiatkowski

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

6 December 2024

Jane J. Yu

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

6 December 2024

language of work or name

English

0 references

publication date

11 July 2011

1 reference

full work available at URL

31 July 2017

http://www.pnas.org/content/108/30/12455.full.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

https://europepmc.org/articles/PMC3145704

6 December 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

https://europepmc.org/articles/PMC3145704?pdf=render

6 December 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

https://doi.org/10.1073/pnas.1104361108

6 December 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21746920

https://pnas.org/doi/pdf/10.1073/pnas.1104361108

6 December 2024

1 reference

DOI

10.1073/PNAS.1104361108

https://api.crossref.org/works/10.1073/PNAS.1104361108

Proceedings of the National Academy of Sciences of the United States of America

6 December 2024

published in

1 reference

31 July 2017

volume

108

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31 July 2017

issue

30

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31 July 2017

page(s)

12455-12460

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Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

31 July 2017

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5 July 2018

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Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

5 July 2018

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

5 July 2018

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Activation of autophagy during cell death requires the engulfment receptor Draper

5 July 2018

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Termination of autophagy and reformation of lysosomes regulated by mTOR

5 July 2018

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5 July 2018

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Specific killing of Rb mutant cancer cells by inactivating TSC2.

5 July 2018

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

5 July 2018

1 reference

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

5 July 2018

1 reference

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Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors

5 July 2018

1 reference

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Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies

5 July 2018

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mTOR signaling at a glance

5 July 2018

1 reference

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Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

Autophagy suppresses tumorigenesis through elimination of p62

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

Molecular mechanisms of mTOR-mediated translational control

5 July 2018

1 reference

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ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation

5 July 2018

1 reference

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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis

5 July 2018

1 reference

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Autophagy fights disease through cellular self-digestion

5 July 2018

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Autophagy in the Pathogenesis of Disease

5 July 2018

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Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis

5 July 2018

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Role of autophagy in cancer

5 July 2018

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IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway

5 July 2018

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5 July 2018

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5 July 2018

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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

5 July 2018

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5 July 2018

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The tuberous sclerosis complex

5 July 2018

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5 July 2018

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5 July 2018

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

5 July 2018

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5 July 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

5 July 2018

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5 July 2018

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Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

5 July 2018

1 reference

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

5 July 2018

1 reference

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TSC2 mediates cellular energy response to control cell growth and survival

5 July 2018

1 reference

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

5 July 2018

1 reference

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Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B

5 July 2018

1 reference

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

A protein conjugation system essential for autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines.

5 July 2018

1 reference

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Effect of Chloroquine on Morphology of Cytoplasmic Granules in Maturing Human Leukocytes—an Ultrastructural Study*

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

Immune and hemorheological changes in chronic fatigue syndrome

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104361108

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104361108

Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104361108

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104361108

Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3145704

28 October 2018

Identifiers

DOI

10.1073/PNAS.1104361108

1 reference

31 July 2017

0 references

1 reference

31 July 2017

1 reference