Structural biology of insulin and IGF1 receptors: implications for drug design (Q34152764)

31 July 2017

1 reference

title

Structural biology of insulin and IGF1 receptors: implications for drug design (English)

1 reference

31 July 2017

1 reference

1 reference

Pierre De Meyts

1

0 references

author name string

Jonathan Whittaker

series ordinal

2

1 reference

31 July 2017

publication date

1 October 2002

1 reference

Nature Reviews Drug Discovery

31 July 2017

published in

1 reference

31 July 2017

volume

1

1 reference

31 July 2017

issue

10

1 reference

31 July 2017

page(s)

769-783

1 reference

New horizons--alternative routes for insulin therapy

31 July 2017

cites work

1 reference

Insulin and insulin-like growth factors: the paradox of signaling specificity

31 March 2020

1 reference

Structure and function of the type 1 insulin-like growth factor receptor.

31 March 2020

1 reference

The effects of insulin-like growth factors on tumorigenesis and neoplastic growth

31 March 2020

1 reference

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

31 March 2020

1 reference

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

31 March 2020

1 reference

High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells

31 March 2020

1 reference

Structure of the human insulin receptor gene and characterization of its promoter

31 March 2020

1 reference

Protein tyrosine kinase structure and function

31 March 2020

1 reference

Ligand-induced dimerization of growth factor receptors: variations on the theme

31 March 2020

1 reference

Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization

31 March 2020

1 reference

Alternative splicing of human insulin receptor messenger RNA.

31 March 2020

1 reference

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity

31 March 2020

1 reference

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

31 March 2020

1 reference

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.

31 March 2020

1 reference

Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

31 March 2020

1 reference

A third fibronectin type III domain in the extracellular region of the insulin receptor family

31 March 2020

1 reference

A third fibronectin-type-III domain in the insulin-family receptors

31 March 2020

1 reference

Members of the insulin receptor family contain three fibronectin type III domains

31 March 2020

1 reference

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

31 March 2020

1 reference

Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.

31 March 2020

1 reference

Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding

31 March 2020

1 reference

Crystal structure of the tyrosine kinase domain of the human insulin receptor

31 March 2020

1 reference

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

31 March 2020

1 reference

Structure and autoregulation of the insulin-like growth factor 1 receptor kinase

31 March 2020

1 reference

Single-molecule imaging of human insulin receptor ectodomain and its Fab complexes

31 March 2020

1 reference

Structural studies of the detergent-solubilized and vesicle-reconstituted insulin receptor

31 March 2020

1 reference

A model for the quaternary structure of human placental insulin receptor deduced from electron microscopy

31 March 2020

1 reference

Membrane topology of insulin receptors reconstituted into lipid vesicles

31 March 2020

1 reference

Quaternary structure of the insulin-insulin receptor complex

31 March 2020

1 reference

Mechanism of transmembrane signaling: insulin binding and the insulin receptor

31 March 2020

1 reference

Single molecule imaging of supported planar lipid bilayer--reconstituted human insulin receptors by in situ scanning probe microscopy

31 March 2020

1 reference

New perspectives into the molecular pathogenesis and treatment of type 2 diabetes

31 March 2020

1 reference

Structure-activity relationship of synthetic phosphoinositolglycans mimicking metabolic insulin action

31 March 2020

1 reference

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

31 March 2020

1 reference

The lipid phosphatase SHIP2 controls insulin sensitivity

31 March 2020

1 reference

Discovery of a Small Molecule Insulin Mimetic with Antidiabetic Activity in Mice

31 March 2020

1 reference

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity

31 March 2020

1 reference

A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo

31 March 2020

1 reference

Tyrosine kinase inhibition: an approach to drug development

31 March 2020

1 reference

Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity

31 March 2020

1 reference

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

31 March 2020

1 reference

Restenosis following angioplasty in the swine coronary artery is inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor, RPR101511A

31 March 2020

1 reference

Mechanism-based design of a protein kinase inhibitor

31 March 2020

1 reference

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

31 March 2020

1 reference

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

31 March 2020

1 reference

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

31 March 2020

1 reference

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies

31 March 2020

1 reference

The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site

31 March 2020

1 reference

Mutational analysis of insulin receptor function: consensus and controversy

31 March 2020

1 reference

Properties of an insulin receptor with an IGF-1 receptor loop exchange in the cysteine-rich region

31 March 2020

1 reference

Mammalian membrane-bound adenylyl cyclases

31 March 2020

1 reference

Identification of a ligand-binding region of the human insulin receptor encoded by the second exon of the gene

31 March 2020

1 reference

Alanine-scanning mutagenesis of a C-terminal ligand binding domain of the insulin receptor alpha subunit

31 March 2020

1 reference

Analog binding properties of insulin receptor mutants. Identification of amino acids interacting with the COOH terminus of the B-chain of the insulin molecule

31 March 2020

1 reference

Congenital insulin resistance associated with a conformational alteration in a conserved beta-sheet in the insulin receptor L1 domain

31 March 2020

1 reference

Activation of glucose transport by a natural mutation in the human insulin receptor

31 March 2020

1 reference

Mutation of arginine 86 to proline in the insulin receptor alpha subunit causes lack of transport of the receptor to the plasma membrane, loss of binding affinity and a constitutively activated tyrosine kinase in transfected cells

31 March 2020

1 reference

Replacements of Leucine 87 in Human Insulin Receptor Alter Affinity for Insulin

31 March 2020

1 reference

Deletion of lysine 121 creates a temperature-sensitive alteration in insulin binding by the insulin receptor.

31 March 2020

1 reference

An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events

31 March 2020

1 reference

A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing

31 March 2020

1 reference

Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site

31 March 2020

1 reference

A model for insulin binding to the insulin receptor

31 March 2020

1 reference

Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor

31 March 2020

1 reference

Fusion of insulin receptor ectodomains to immunoglobulin constant domains reproduces high-affinity insulin binding in vitro

31 March 2020

1 reference

High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

31 March 2020

1 reference

Receptor-binding region of insulin

31 March 2020

1 reference

Receptor binding redefined by a structural switch in a mutant human insulin

31 March 2020

1 reference

A structural switch in a mutant insulin exposes key residues for receptor binding

31 March 2020

1 reference

Alanine scanning mutagenesis of insulin

31 March 2020

1 reference

Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions

31 March 2020

1 reference

Mutational analysis of invariant valine B12 in insulin: implications for receptor binding

31 March 2020

1 reference

Structural origins of the functional divergence of human insulin-like growth factor-I and insulin

31 March 2020

1 reference

Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions

31 March 2020

1 reference

Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding

31 March 2020

1 reference

A single-chain insulin-like growth factor I/insulin hybrid binds with high affinity to the insulin receptor

31 March 2020

1 reference

Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor.

31 March 2020

1 reference

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

31 March 2020

1 reference

The insulin‐binding domain of insulin receptor is encoded by exon 2 and exon 3

31 March 2020

1 reference

High-resolution structures of the ligand binding domain of the wild-type bacterial aspartate receptor

31 March 2020

1 reference

Functional reconstitution of insulin receptor binding site from non-binding receptor fragments

31 March 2020

1 reference

Rational design of potent antagonists to the human growth hormone receptor

31 March 2020

1 reference

Biological effects of growth hormone and its antagonist

31 March 2020

1 reference

Single-chain vascular endothelial growth factor variant with antagonist activity

31 March 2020

1 reference

Properties of small molecules affecting insulin receptor function

31 March 2020

1 reference

Erythropoietin mimetic peptides and the future

31 March 2020

1 reference

A hot spot of binding energy in a hormone-receptor interface

31 March 2020

1 reference

Phage display for selection of novel binding peptides

31 March 2020

1 reference

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

31 March 2020

1 reference

Increased potency of an erythropoietin peptide mimetic through covalent dimerization

31 March 2020

1 reference

Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity

31 March 2020

1 reference

Activation of erythropoietin receptor through a novel extracellular binding site

31 March 2020

1 reference

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

31 March 2020

1 reference

Mimicry of erythropoietin by a nonpeptide molecule

31 March 2020

1 reference

Site-directed ligand discovery

31 March 2020

1 reference

An evolutionary approach for structure-based design of natural and non-natural peptidic ligands

31 March 2020

1 reference

Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site

31 March 2020

1 reference

Peptides identify the critical hotspots involved in the biological activation of the insulin receptor

31 March 2020

1 reference

Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.

31 March 2020

1 reference

The relationship between the L1 and L2 domains of the insulin and epidermal growth factor receptors and leucine-rich repeat modules

31 March 2020

1 reference

Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor

31 March 2020

1 reference

The Disulfide Bonds in the C-terminal Domains of the Human Insulin Receptor Ectodomain

31 March 2020

1 reference

Identification of the cysteine residues involved in the class I disulfide bonds of the human insulin receptor: properties of insulin receptor monomers

31 March 2020

1 reference

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

31 March 2020

1 reference

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

31 March 2020

1 reference

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

31 March 2020

1 reference

The insulin receptor: from protein sequence to structure.

31 March 2020

1 reference

Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.

31 March 2020

1 reference

Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies

31 March 2020

1 reference

Isolation of a proteolytically derived domain of the insulin receptor containing the major site of cross-linking/binding

31 March 2020

1 reference

Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit

31 March 2020

1 reference

Structure of the extracellular region of HER3 reveals an interdomain tether

31 March 2020

1 reference

The structure of 2Zn pig insulin crystals at 1.5 A resolution

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD917

1 reference

31 July 2017

1 reference